The early effect of dapagliflozin on diastolic function parameters in patients with mid range and reduced ejection fraction heart failure | ||
| Benha Journal of Applied Sciences | ||
| Article 1, Volume 9, Issue 12, December 2024, Pages 1-4 PDF (273.66 K) | ||
| Document Type: Original Research Papers | ||
| DOI: 10.21608/bjas.2024.340860.1541 | ||
| Authors | ||
| Ahmed Abdel Aziz Mohamed* 1; Elsayyed Abdelkhalek Eldarky2; Ali Ibrahim Ateya3; Hagar Ibrahim Allam4 | ||
| 1Cardiology Dept., Faculty of Medicine, Benha Univ., Benha, Egypt | ||
| 2Professor of Cardiology Faculty of Medicine – Benha University | ||
| 3Assistant Professor of Cardiology Faculty of Medicine – Benha University | ||
| 4Lecturer of Cardiology Faculty of Medicine – Benha University | ||
| Abstract | ||
| Cardiovascular mortality and hospitalisation rates were greatest among heart failure (HF) patients with reduced ejection fraction (HFrEF) according to clinical trial data. Treatment of heart failure with sodium-glucose transporter-2 inhibitors (SGLT2i) has recently made significant strides [1]. Even in patients with HFrEF, LV diastolic dysfunction was a separate predictor of outcome [2]. It is essential to identify structural abnormalities using echocardiography since they have been linked to prognosis in HF and DM patients [3]. Both diabetic and non-diabetes patients with HF have had their risk of death and hospital readmission decreased by SGLT2is, according to large-scale randomised studies and meta-analyses [4]. These are part of the global guidelines for the treatment of heart failure (HF) at the intermediate assessment level [5]. Some theories suggest that SGLT2is exerts its cardioprotective effects by reversing cardiac remodelling [6] and restoring systolic and diastolic function [7].Some theories suggest that SGLT2is exerts its cardioprotective effects by reversing cardiac remodelling and restoring systolic and diastolic function | ||
| Keywords | ||
| heart failure; sodium-glucose transporter-2 inhibitor; diastolic function | ||
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