Combined Main Branch Stenting and Side Branch Drug-Coated Balloon versus Two-Stent Strategy in Patients with Left Main Bifurcation Lesions
Sadek, Y., El-husseiny, M., El-Rabbat, K., Tabl, M., Bendary, A. (2025). Combined Main Branch Stenting and Side Branch Drug-Coated Balloon versus Two-Stent Strategy in Patients with Left Main Bifurcation Lesions. EKB Journal Management System, (), -. doi: 10.21608/bmfj.2025.342979.2277
Yasser Sadek; Mohamed El-husseiny; Khalid El-Rabbat; Mohamed Tabl; Ahmed Bendary. "Combined Main Branch Stenting and Side Branch Drug-Coated Balloon versus Two-Stent Strategy in Patients with Left Main Bifurcation Lesions". EKB Journal Management System, , , 2025, -. doi: 10.21608/bmfj.2025.342979.2277
Sadek, Y., El-husseiny, M., El-Rabbat, K., Tabl, M., Bendary, A. (2025). 'Combined Main Branch Stenting and Side Branch Drug-Coated Balloon versus Two-Stent Strategy in Patients with Left Main Bifurcation Lesions', EKB Journal Management System, (), pp. -. doi: 10.21608/bmfj.2025.342979.2277
Sadek, Y., El-husseiny, M., El-Rabbat, K., Tabl, M., Bendary, A. Combined Main Branch Stenting and Side Branch Drug-Coated Balloon versus Two-Stent Strategy in Patients with Left Main Bifurcation Lesions. EKB Journal Management System, 2025; (): -. doi: 10.21608/bmfj.2025.342979.2277

Combined Main Branch Stenting and Side Branch Drug-Coated Balloon versus Two-Stent Strategy in Patients with Left Main Bifurcation Lesions

Benha Medical Journal
Articles in Press, Accepted Manuscript, Available Online from 18 January 2025  XML PDF (295.12 K)
Document Type: Original Article
DOI: 10.21608/bmfj.2025.342979.2277
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Authors
Yasser Sadek1; Mohamed El-husseiny email 2; Khalid El-Rabbat3; Mohamed Tabl3; Ahmed Bendaryorcid 3
1Department of Cardiology , Faculty of Medicine, Helwan University, Cairo, Egypt.
2M.B.B.CH, MSc Cardiology Department, Faculty of Medicine, Benha University, Benha, Egypt.
3Department of Cardiology , Faculty of Medicine, Benha University, Benha, Egypt.
Abstract
Background: Left Main Coronary Artery (LMCA) disease is a high-risk subset of coronary artery disease, with bifurcation lesions comprising nearly 50% of cases. Advances in percutaneous coronary intervention (PCI) using drug-eluting stents (DES) and drug-coated balloons (DCB) offer novel treatment options. This study compares the efficacy and safety of DES with DCB versus the conventional two-stent technique in treating left main bifurcation lesions. Methods: This observational study included 60 patients with true left main bifurcation lesions undergoing revascularization at Benha University. Patients were divided into two groups: Group I (DES + DCB) and Group II (2-DES). Pre- and post-procedure intravascular ultrasound (IVUS) assessments were performed. All participants received dual antiplatelet therapy and statins. Follow-up was conducted over six months through medical records, outpatient visits, and telephone consultations. Results: In the LAD artery, the 2-DES group demonstrated lower postoperative luminal stenosis (8.4 ± 1.8%) compared to DES + DCB (10.19 ± 1.58%, P = 0.003). In the left circumflex artery, the 2-DES group had a higher minimum luminal diameter (3.3 ± 0.27 mm vs. 3 ± 0.37 mm, P = 0.01) and lower luminal stenosis (12.02 ± 2.42% vs. 20.31 ± 3.85%, P < 0.001). Major adverse cardiac events (MACE) occurred in 10% of the 2-DES group and 3.3% of the DES + DCB group (P = 0.612). Conclusion: The two-stent technique achieved superior immediate postoperative luminal outcomes, while DES + DCB demonstrated comparable safety and efficacy with a lower incidence of MACE at six months.
Keywords
Left Main Coronary Artery; Bifurcation Lesions; Drug-Eluting Stents; Drug-Coated Balloons; Percutaneous Coronary Intervention
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