Comparison between Non-alcoholic fatty liver disease Fibrosis Score in Diabetic and Non-diabetic Egyptian patients
Hammad, O., Haseeb, A., Abdel Aziz, M., Naguib, M. (2025). Comparison between Non-alcoholic fatty liver disease Fibrosis Score in Diabetic and Non-diabetic Egyptian patients. EKB Journal Management System, 6(1), 52-63. doi: 10.21608/ejmr.2022.121681.1198
Osama Mohamed Hammad; Alaa Farouk Haseeb; Manar Mahmoud Abdel Aziz; Michael Nady Naguib. "Comparison between Non-alcoholic fatty liver disease Fibrosis Score in Diabetic and Non-diabetic Egyptian patients". EKB Journal Management System, 6, 1, 2025, 52-63. doi: 10.21608/ejmr.2022.121681.1198
Hammad, O., Haseeb, A., Abdel Aziz, M., Naguib, M. (2025). 'Comparison between Non-alcoholic fatty liver disease Fibrosis Score in Diabetic and Non-diabetic Egyptian patients', EKB Journal Management System, 6(1), pp. 52-63. doi: 10.21608/ejmr.2022.121681.1198
Hammad, O., Haseeb, A., Abdel Aziz, M., Naguib, M. Comparison between Non-alcoholic fatty liver disease Fibrosis Score in Diabetic and Non-diabetic Egyptian patients. EKB Journal Management System, 2025; 6(1): 52-63. doi: 10.21608/ejmr.2022.121681.1198

Comparison between Non-alcoholic fatty liver disease Fibrosis Score in Diabetic and Non-diabetic Egyptian patients

Egyptian Journal of Medical Research
Volume 6, Issue 1, January 2025, Page 52-63  XML PDF (834.14 K)
Document Type: Original Article
DOI: 10.21608/ejmr.2022.121681.1198
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Authors
Osama Mohamed Hammad1; Alaa Farouk Haseeb1; Manar Mahmoud Abdel Aziz2; Michael Nady Naguib email 1
1Endemic Medicine Department, Faculty of Medicine Beni-Suef University, Egypt
2Clinical and chemical pathology department, faculty of medicine, benisuef university
Abstract
The aim of the present study was to compare NAFLD fibrosis score in diabetic and non-diabetic Egyptian patients to clarify the effect of diabetes on the development of fibrosis and NASH in NAFLD patients. This was a comparative anterospective observational study. 50 Egyptian patients with characteristic sonographic features and laboratory findings suggesting Non-alcoholic fatty liver disease were included. The patients were divided into two groups; Diabetic group and Non-diabetic group according to American diabetic association criteria 2015 comparing the NAFLD fibrosis score in both groups which uses six commonly measured parameters. Mean ±SD of NAFLD fibrosis score was -7.5± 0.97 in the non-diabetic group and 1.58± 1.9 in the diabetic group showing significant difference among the studied groups, as the lowest scores were in non-diabetic group, and the highest scores were in the diabetic group. This showing prevalence of advanced hepatic disease in Diabetic group more than non-diabetic group. The lower serum albumin and platelet count in combination with a higher AST to ALT ratio seen with the DM patients reflect the higher prevalence of advanced fibrosis as they are recognized markers of hepatic synthetic function, portal hypertension and surrogates of advanced fibrosis respectively. We concluded that; more aggressive NAFLD as suggested by the higher NAFLD fibrosis score was seen in DM patients compared to non-DM patients.
Keywords
NAFLD; Type 2 Diabetes mellitus; NAFLD Fibrosis Score
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