Synthesis, Enantio-Separation and Molecular Docking Study of Hesperidin-Oxime | ||||
| Egyptian Journal of Chemistry | ||||
| Volume 68, Issue 5, May 2025, Page 401-408 PDF (1.01 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejchem.2025.333625.10739 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Meriem BOUANINI ; Nasser Belboukhari  ; Khaled Sekkoum; Djawhara Haddad
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| univ TM Bechar, Fac sciences exactes, bechar PO 417 Bechar, Algerie | ||||
| Abstract | ||||
| This study aims to synthesize hesperidin oxime from hesperidin, chiral separation by HPLC method and comparative study of two enantiomers as anti-inflammatory agents by docking them with Proto-oncogene serine/threonine-protein kinase Pim-1 using MOE software (4.2). The structure of the synthesized product was validated through UV, IR,1H-NMR, and13C-NMR spectroscopic techniques. Hesperidin-oxime was separated chirally in normal phase mode employing polysaccharide-based chiral stationary phases, namely Chiralcel® OD-H, Chiralcel® OD-RH, and CHIRALPAK® AD-3R, under both normal and polar organic phase modes. Molecular docking shows that S- hesperidin oxime gave better binding affinity towards pim-1 compared to R- hesperidin oxime. | ||||
| Keywords | ||||
| Hesperidin oxime; HPLC; molecular docking; Pim-1; anti-inflammatory | ||||
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