Detection of the Ameliorative and Antioxidant Effects of Pumpkin Seed Oil and Olive Oil on DBP-Induced Nephrotoxicity in Male Albino Rats by Investigating their Protective Properties on Physiological and Histological Measures | ||||
| Egyptian Journal of Veterinary Sciences | ||||
| Articles in Press, Corrected Proof, Available Online from 23 January 2025 PDF (2.92 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejvs.2025.340222.2527 | ||||
 View on SCiNiTO | ||||
| Author | ||||
Manal R. Bakeer 
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| Physiology Department, Faculty of Veterinary Medicine, Cairo University, Giza 12211, Egypt. | ||||
| Abstract | ||||
| The present research assessed the protective properties of pumpkin (Cucurbita pepo L) and olive (Olea europaea L) oil on di-n-butyl phthalate (DBP)-induced renal damage in rats. This study employed 30 albino male rats, six per group. Group one "control" (C); group two (DBP) was treated with DBP (500 mg/kg/day); group three (DP) was treated with DBP and supplemented with pumpkin oil (288 mg/kg bwt/daily); group four (DO) was treated with DBP and supplemented with olive oil (1.5 ml/kg bwt/daily); and group five (DPO) was treated with DBP and supplemented with both pumpkin and olive oils. The experiment lasted for two months. Serum levels of creatinine, urea and uric acid, oxidative stress markers and histological changes, were investigated. TAC, SOD, and ALP levels decreased significantly, but MDA, creatinine, urea and uric acid levels increased. Histopathological lesions in kidney tissue of the DBP-exposed group were found. In conclusion, supplementing rats with pumpkin or olive oil under oxidative stress resulted in better oxidative state of the kidney, kidney function tests, and renal tissue histology. | ||||
| Keywords | ||||
| Nephrotoxicity; pumpkin oil; olive oil; dibutyl phthalate | ||||
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