Neutrophil to Lymphocyte Ratio and Interleukin-6 Level in Evaluation of Inflammation in Chronic Hemodialysis Patients with and without Residual Kidney Functions
Mustafa, N., El Nahas, M., Badreldin, B., Elmaghrabi, H., Megahed, A. (2025). Neutrophil to Lymphocyte Ratio and Interleukin-6 Level in Evaluation of Inflammation in Chronic Hemodialysis Patients with and without Residual Kidney Functions. EKB Journal Management System, 22(22), 1-11. doi: 10.21608/muj.2025.350949.1200
Noha A Mustafa; Mamdouh El Nahas; Basma Badreldin; Hanzada Elmaghrabi; Ahmed Samir Megahed. "Neutrophil to Lymphocyte Ratio and Interleukin-6 Level in Evaluation of Inflammation in Chronic Hemodialysis Patients with and without Residual Kidney Functions". EKB Journal Management System, 22, 22, 2025, 1-11. doi: 10.21608/muj.2025.350949.1200
Mustafa, N., El Nahas, M., Badreldin, B., Elmaghrabi, H., Megahed, A. (2025). 'Neutrophil to Lymphocyte Ratio and Interleukin-6 Level in Evaluation of Inflammation in Chronic Hemodialysis Patients with and without Residual Kidney Functions', EKB Journal Management System, 22(22), pp. 1-11. doi: 10.21608/muj.2025.350949.1200
Mustafa, N., El Nahas, M., Badreldin, B., Elmaghrabi, H., Megahed, A. Neutrophil to Lymphocyte Ratio and Interleukin-6 Level in Evaluation of Inflammation in Chronic Hemodialysis Patients with and without Residual Kidney Functions. EKB Journal Management System, 2025; 22(22): 1-11. doi: 10.21608/muj.2025.350949.1200

Neutrophil to Lymphocyte Ratio and Interleukin-6 Level in Evaluation of Inflammation in Chronic Hemodialysis Patients with and without Residual Kidney Functions

Medicine Updates
Volume 22, Issue 22, July 2025, Page 1-11  XML PDF (856.42 K)
Document Type: Research project
DOI: 10.21608/muj.2025.350949.1200
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Authors
Noha A Mustafa email 1; Mamdouh El Nahas2; Basma Badreldin3; Hanzada Elmaghrabi4; Ahmed Samir Megahed4
1Internal medicine,faculty of medicine, portsaid university, portsaid, Egypt
2prof of internal medicine port said university
3Faulty of medicine Port said university
4Lecturer of nephrology, internal medicine department, faculty of medicine, portsaid university, Egypt
Abstract
Background: Chronic inflammation is a main characteristic of chronic kidney disease (CKD) and is exacerbated in patients undergoing hemodialysis (HD). Residual kidney function (RKF) plays a vital role in mitigating inflammation. We aimed to assess the utility of neutrophil-to-lymphocyte ratio (NLR) and interleukin-6 (IL-6) as inflammatory markers in HD cases with and without RKF.
Methods: A cross-sectional study was conducted on 100 CKD cases on HD, categorized into two groups based on RKF presence. NLR and IL-6 levels were measured and analyzed in relation to demographic, clinical, and biochemical parameters. Statistical analysis included correlation studies and receiver operating characteristic (ROC) curve analysis.
Results: IL-6 levels and NLR were significantly increased in cases without RKF (p < 0.05). ROC analysis revealed IL-6 as a better marker for predicting loss of RKF compared to NLR. Correlations were observed between IL-6 levels, inflammatory markers, and renal parameters.
Conclusions: IL-6 and NLR are useful biomarkers for assessing inflammation in HD patients, with IL-6 demonstrating superior predictive value for RKF status. Monitoring these markers can provide insights into inflammation management in CKD.
Keywords
CKD; Hemodialysis; Residual kidney function; Interleukin-6; Neutrophil-to-lymphocyte ratio
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