Effect of Oral Silymarin on Liver Function, Antioxidants Activity and Blood Lipid Profile of Induced Hepatic Injury Growing Rabbits | ||||
| Egyptian Journal of Veterinary Sciences | ||||
| Articles in Press, Corrected Proof, Available Online from 26 January 2025 PDF (1.16 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejvs.2025.332416.2460 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Eman A. El-Said1; Khaled M. Elattar  2; Ayman Y. El-Khateeb3; Sahar E. Hamed4
| ||||
| 1Animal, Poultry and Fish Production Department, Faculty of Agriculture, Damietta University, Damietta, Egypt. | ||||
| 2Unit of Genetic Engineering and Biotechnology, Faculty of Science, Mansoura University, El-Gomhoria Street, Mansoura, 35516, Egypt. | ||||
| 3Agricultural Chemistry Department, Faculty of Agriculture, Mansoura University, Egypt | ||||
| 4Chemistry Department, Faculty of Agriculture, Damietta University, Damietta, 22052, Egypt. | ||||
| Abstract | ||||
| Objective: This work explored the HPLC method of silymarin in preventing CCl4 induced hepatotoxicity in New Zealand albino rabbits in an aspect of its anti-inflammatory and lipid-lowering effects. Methods: Seventy-five NZW male rabbits, aged eight weeks, were randomly assigned into five equal groups. The first group served as the control and did not receive any treatment, while the other four groups were administered a subcutaneous injection of CCl4 (0.5 ml) twice weekly for three weeks. After CCl4 administration, the treated groups were provided with the basal control diet supplemented with silymarin at doses of 25, 50, or 75 mg/kg body weight for six weeks. Results: Oral silymarin at 50 and 75 mg/kg improved hepato-testicular weights compared to this study's CCl4-induced liver injury group. Among these three doses, the dose of 50 mg/kg enhanced the highest level in total serum proteins such as total protein, albumin, and globulin as well as in thyroid proteins. Additionally, the dose of the extract within the current experiment also exhibited a relatively significant antioxidant impact that enhances liver functions by reducing the content of ALT, AST, and ALP. Also, in the group treated with silymarin at 50 mg/kg, there was a hypocholesterolemic action manifesting reduced serum cholesterol, LDL, and triglyceride while elevated HDL cholesterol compared to other groups. Conclusion: Dietary silymarin supplementation, particularly at 50 mg/kg, appears to be a promising strategy for improving antioxidant activity, liver function, and blood lipid profile in rabbits experiencing CCl4-induced hepatic injury. This suggests its potential for alleviating these conditions. | ||||
| Keywords | ||||
| Silymarin; hypocholesterolemic; liver function; antioxidant; and IL-6 | ||||
|
Statistics Article View: 117 PDF Download: 99 |
||||
