Measurement of serum macrophage migration inhibitory factor level in patients with external ano-genital warts treated with intralesional purified protein derivative injection: an interventional study | ||||
| Human Andrology | ||||
| Volume 13, Issue 13, January 2023, Page 1-9 PDF (1.74 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ha.2023.178784.1097 | ||||
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| Authors | ||||
Hesham Nada1; Mohamed Osama Abdaalla2; Ahmed Adel Abd El Fattah Yousef3; Mohamed Azab   4
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| 1Assistant Professor at Dermatology, Venereology and Andrology Department, Faculty of Medicine, Suez Canal University, Ismailia, Egypt. | ||||
| 2Lecturer at Clinical Pathology Department , Faculty of Medicine, Suez Canal University, Ismailia, Egypt | ||||
| 3Resident of Dermatology El Houd El Marsoud Hospital, Ministry of Health,Cairo,Egypt. | ||||
| 4Assistant Professor of Andrology, Infertility and Sexually Transmitted diseases, Department of Dermatology, Venerology and Andrology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt | ||||
| Abstract | ||||
| Background: The most prevalent sexually transmitted disease is anogenital warts (AGW), which are produced by different genotypes of the human papilloma virus (HPV). Immunotherapy promotes a delayed type hypersensitive reaction to a variety of antigens as well as to wart tissue. Aim: To evaluate the serum level of macrophage migration inhibitory factor (MIF) in patients with external ano-genital warts before and after intra-lesional purified protein derivative (PPD) injection. Patients and Methods: This study was carried out as pre–post interventional study on 40 patients with external anogenital warts. The study was conducted at the dermatology clinic and the andrology, infertility and sexually transmitted diseases clinic, Suez Canal University Hospital in Ismailia. Using an insulin syringe, each patient was injected 0.2 ml of tuberculin PPD (containing 10 TU of tuberculin PPD) intra-lesionally in the largest wart at regular interval of 2 weeks for a maximum of six injections or less in cases of complete clearance of wart. Serum levels of MIF were measured using ELISA before and after intra-lesional PPD injection. Results: 22 (55%) patients achieved complete response while 8 (20%) patients achieved partial response. No response occurred in 10 (25%) patients. Serum level of MIF after PPD injection was significantly higher than serum level of MIF before PPD injection. There was statistically significant relation between serum MIF level after PPD injection and clinical response to PPD injection. Conclusion: Immunotherapy with intralesional PPD injection provides an efficient, financially viable method of treating genital warts. Serum levels of MIF in patients with anogenital warts after intralesional PPD injection were significantly higher than serum levels of MIF before intralesional PPD injection and have statistically significant relation to clinical response to intralesional PPD injection. | ||||
| Keywords | ||||
| Genital warts; migration inhibitory factor; tuberculin purified protein derivative | ||||
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