A clinical, endoscopic and histopathological study for upper gastrointestinal findings in adult Egyptian patients with ulcerative colitis | ||||
Egyptian Pharmaceutical Journal | ||||
Article 1, Volume 24, Issue 2, April 2025, Page 141-151 PDF (3.48 MB) | ||||
DOI: 10.21608/epj.2025.407379 | ||||
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Authors | ||||
Omar R. Elwakil1; Waleed A. Hamed1; Ola H. Nada2; Ethar M. Badran1 | ||||
1Department of aTropical Medicine, Faculty of Medicine, Ain Shams University, Cairo, Egypt | ||||
2Department of bPathology,Faculty of Medicine, Ain Shams University, Cairo, Egypt | ||||
Abstract | ||||
Background Ulcerative colitis(UC)isatypeofchronicinflammatoryboweldiseaseinthecolon thatisstillofunknownaetiology.What is known, till now,isthatUCisconfinedtothe colonstartingattherectumandextendingproximallyforavariabledistancetill reaching the cecum,anddespiteUCisknowntohavevariousextracolonic presentations,theuppergastrointestinaltract(UGIT)isnotgenerallyconsidered as target organ. Aim ThecurrentstudyaimedtodescribeUGITclinical, endoscopic, and histopathologicalfindingsinadultEgyptianpatientswithUC. Patients and methods Thestudywasconductedon56UCpatients.IntheTropicalMedicineDepartment Faculty of Medicine, AinShamsUniversity.Allthepatientsweresubjectedtofull historytakingandthoroughclinicalexamination.UGITendoscopywasperformed onallpatientstostudytheendoscopicfindingsintheoesophagus, stomach, and duodenumandtotakebiopsiesforhistopathologicalexamination. Results Thecurrentstudyhasshownthat60.7%ofpatientshadgastroesophagealreflux diseaseuponesophagogastroduodenoscopywhilemicroscopicevaluationof oesophagealbiopsiesshowedthat50%ofthecaseswerehavingesophagitis. Regardinggastroduodenalaffection, UGITendoscopyrevealedthat91.1%ofthe patientshadgastritisand78.6%hadduodenitis, histopathological examination of thebiopsysamplesrevealedthat53.6%ofthecaseshadchronicnonspecific gastritis,33.9%ofthecasesshowedchronicgastritiswithhelicobacterpylori infectionand85.7%hadchronicnonspecificduodenitis.The present study showedthatUGITaffectionwasdiagnosedcollectivelyin96.4and87.5%ofthe casesbyendoscopyandbiopsy, respectively. Conclusion ThecurrentstudyhasprovedtheassociationbetweenUCandthepresenceof endoscopic findings in the esophagus, stomach, and duodenum.These findings wereconfirmedbyhistopathologicalexaminationofmucosalbiopsiestakenfrom the esophagus, stomach, and duodenum. | ||||
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