Serum Endocan Levels in Patients with Psoriasis Vulgaris as a Marker of Disease Severity
Elgharib, I., Khalifa, N., Elasser, O., ElGhareeb, M., Hosny, D. (2020). Serum Endocan Levels in Patients with Psoriasis Vulgaris as a Marker of Disease Severity. EKB Journal Management System, 26(3), 517-523. doi: 10.21608/zumj.2019.13587.1252
Ibrahim Elgharib; Naglaa Khalifa; Ola Elasser; Mohamed ElGhareeb; Doaa Hosny. "Serum Endocan Levels in Patients with Psoriasis Vulgaris as a Marker of Disease Severity". EKB Journal Management System, 26, 3, 2020, 517-523. doi: 10.21608/zumj.2019.13587.1252
Elgharib, I., Khalifa, N., Elasser, O., ElGhareeb, M., Hosny, D. (2020). 'Serum Endocan Levels in Patients with Psoriasis Vulgaris as a Marker of Disease Severity', EKB Journal Management System, 26(3), pp. 517-523. doi: 10.21608/zumj.2019.13587.1252
Elgharib, I., Khalifa, N., Elasser, O., ElGhareeb, M., Hosny, D. Serum Endocan Levels in Patients with Psoriasis Vulgaris as a Marker of Disease Severity. EKB Journal Management System, 2020; 26(3): 517-523. doi: 10.21608/zumj.2019.13587.1252

Serum Endocan Levels in Patients with Psoriasis Vulgaris as a Marker of Disease Severity

Zagazig University Medical Journal
Article 19, Volume 26, Issue 3, May 2020, Pages 517-523    PDF (1.05 M)
Document Type: Original Article
DOI: 10.21608/zumj.2019.13587.1252
Authors
Ibrahim Elgharib1; Naglaa Khalifa2; Ola Elasser1; Mohamed ElGhareeb3; Doaa Hosny* 4
1Dermatology,venereology&Andrology Department,Faculty of Medicine,Zagazig University,Zagazig,Egypt
2Department of Clinical Pathology,Faculty of Medicine,Zagazig University,Zagazig, Egypt
3Dermatology,Venereology&Andrology Department, Faculty of Medicine, Zagazig University,Zagazig,Egypt
4Dermatology, Venereology & Andrology Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
Abstract
ABSTRACT
Background: Endocan is a specific molecule of human endothelial cell. It was accepted as a marker of endothelial dysfunction that is widely involved in psoriasis development. Our aim was to evaluate the relation between serum endocan levels and severity of psoriasis vulgaris .
Methods: Twenty-two patients with psoriasis vulgaris were involved . We measured serum endocan, c-reactive protein (CRP) and erythrocyte sedimentation rate (ESR). Psoriasis severity was evaluated by Psoriasis Area and Severity Index (PASI) score.
Results: The mean serum level of endocan was 154±49.3 pg/ml with a range from 59 to 210 pg/ml. Its level was statistically significant increase in moderate and severe psoriatic patients compared to mild psoriatic patients. No statistically significant correlations were detected between serum endocan and CRP (P=0.11) and ESR(P=0.16). In contrast, a very highly statistically significant positive correlation was detected between endocan and disease severity(p=0.001).
Conclusions: Serum endocan can be a promising marker that correlates with psoriasis vulgaris severity.
Keywords
endocan; Psoriasis; endothelial dysfunction
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