Effects of Day 3 Versus Day 5 PGT-A Embryo Biopsies on IVF/ICSI Cycles Outcome : Α Systematic Review and Meta-Analysis | ||
| Evidence Based Women's Health Journal | ||
| Article 11, Volume 15, Issue 15, January 2025, Pages 1-8 PDF (507.04 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ebwhj.2024.335436.1381 | ||
| Authors | ||
| ibrahim badr* 1; Ahmed Shaban2; Mazen Anas2; Mohamed Kamal2 | ||
| 1Department of Obstetrics & Gynecology , Cairo University's faculty of medicine | ||
| 2Department of Obstetrics and Gynecology, Cairo University, Faculty of Medicine, Egypt | ||
| Abstract | ||
| Background: The effectiveness of pre-implantation genetic testing for aneuploidy (PGT-A) remains a topic of intense debate. Objectives: Is to determine the optimal time for PGT-A biopsies. Methods: Up until May 2024, MEDLINE/PubMed, Embase, and the Cochrane Central Library were searched thoroughly for relevant literature. PGT-A with comprehensive chromosomal screening (CCS) on Days 3 and 5 was used in 11 randomized controlled studies. Results: In the overall population, PGT-A did not increase live-birth rates (LBR) per patient (RR:1.11; 95%CI:0.87-1.42; n=1513; I2=75%). Nonetheless, PGT-A reduced the whole population's miscarriage rate (RR:0.45; 95%CI:0.25-0.80; n=912; I2=49%). Remarkably, PGT-A increased cumulative LBR per patient (RR:1.36; 95%CI:1.13-1.64; n=580; I2=12%). Only the day-5 biopsy procedure showed enhanced LBR per ET in terms of optimal scheduling (RR: 1.37; 95% CI: 1.03-1.82; I2=72%). Conclusion: PGT-A only increased live-birth rates when applied to embryos at the blastocyst phase; it had no effect on clinical results for the overall population | ||
| Keywords | ||
| Blastocyst; day 3; IVF/ICSI; live birth rate; PGT-A | ||
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