Chronic Unpredictable Mild Stress Induced Cognitive Impairment: AMPK/mTOR Autophagic Signaling
Eladawy, R., El-Sayed, R., Ahmed, L., Mohamed, A., Salem, H. (2025). Chronic Unpredictable Mild Stress Induced Cognitive Impairment: AMPK/mTOR Autophagic Signaling. EKB Journal Management System, 1(3), 73-83. doi: 10.21608/sisj.2025.407751
Reem M Eladawy; Rehab M. El-Sayed; Lamiaa A. Ahmed; Ahmed F. Mohamed; Hesham A. Salem. "Chronic Unpredictable Mild Stress Induced Cognitive Impairment: AMPK/mTOR Autophagic Signaling". EKB Journal Management System, 1, 3, 2025, 73-83. doi: 10.21608/sisj.2025.407751
Eladawy, R., El-Sayed, R., Ahmed, L., Mohamed, A., Salem, H. (2025). 'Chronic Unpredictable Mild Stress Induced Cognitive Impairment: AMPK/mTOR Autophagic Signaling', EKB Journal Management System, 1(3), pp. 73-83. doi: 10.21608/sisj.2025.407751
Eladawy, R., El-Sayed, R., Ahmed, L., Mohamed, A., Salem, H. Chronic Unpredictable Mild Stress Induced Cognitive Impairment: AMPK/mTOR Autophagic Signaling. EKB Journal Management System, 2025; 1(3): 73-83. doi: 10.21608/sisj.2025.407751

Chronic Unpredictable Mild Stress Induced Cognitive Impairment: AMPK/mTOR Autophagic Signaling

Sinai International Scientific Journal
Volume 1, Issue 3, January 2025, Page 73-83  XML PDF (876.9 K)
Document Type: Narrative Review Article
DOI: 10.21608/sisj.2025.407751
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Authors
Reem M Eladawy email orcid 1; Rehab M. El-Sayedorcid 1; Lamiaa A. Ahmed2; Ahmed F. Mohamed2, 3; Hesham A. Salem1, 2
1Pharmacology & Toxicology Department, Faculty of Pharmacy, Sinai University – Arish Branch, Arish, Egypt
2Pharmacology & Toxicology Department, Faculty of Pharmacy, Cairo University, Cairo, Egypt
3Pharmacology & Toxicology Department, Faculty of Pharmacy, King Salman International University, South Sinai, Egypt
Abstract
        Chronic stress is linked to a variety of neuropsychiatric ailments, many of which are characterized by cognitional alterations. Stress animal models showed equivalent behavioural alterations, including working memory and cognitive flexibility impairment. It's consistent with morphological alterations in the hippocampus and frontal cortex, all of which play important roles in controlling these behaviours. Growing evidence suggests that changes in autophagy could be contributing to the disorders observed in neuropsychiatric diseases. Chronic stress can affect autophagy signaling in the hippocampus and frontal cortex; besides, this is believed to be related to changes in neuronal morphology. Recently, animal models have explained the function of autophagy signaling in behavioural changes caused by stress. Together, the findings indicate that autophagy plays an essential role in mediating cognitive impairment seen in the presence of stress. Increasing our knowledge of the effects of stress on AMPK/mTOR autophagic signaling will eventually support the discovery of more effective medications for people suffering from cognitive impairment.
Copyright © 20xx by the authors. This article is an open access article distributed under the terms and conditions Creative Commons Attribution-Share Alike 4.0 International Public License (CC BY-SA 4.0)        
        
Keywords
CUMS; Cognitive impairment; Autophagy; AMPK/mTOR
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