Secondary metabolites and bioactivity of two fungal strains | ||
| Egyptian Pharmaceutical Journal | ||
| Volume 11, Issue 1, June 2012, Pages 16-21 PDF (416.96 K) | ||
| DOI: 10.7123/01.EPJ.0000415591.30981.86 | ||
| Authors | ||
| Mohamed M.S. Nagia; Mohamed Shaaban; Mohamed S. Abdel-Aziz; Soheir M. El-Zalabani; Atef Gobran Hanna | ||
| Abstract | ||
| Purpose The investigation of two fungal strains isolated from Egyptian habitats, namely, the endophytic FUN1 and the terrestrial FUN2 to illustrate their chemical constituents and their bioactivities. Materials and methods See General instrumental procedures. Results Linoleic acid (1), indole-3-acetic acid methyl ester (2) and Nb-acetyltryptamine (3) were produced by FUN1, whereas FUN2 also delivered linoleic acid (1) in addition to cis-cyclo-(prolyl, valyl) (4). The structures of compounds (1)–(4) were elucidated by 1D and 2D NMR, MS data and through comparison with literature reports. In this article, the taxonomical characterization of both fungal strains, their upscale fermentation and the antimicrobial and cytotoxic activities tested have been described. Conclusion Two different fungal strains, endophytic FUN1 and terrestrial FUN2, were intensively studied biologically and chemically. Four bioactive compounds (1)–(4) were isolated, and structurally confirmed by intensive studies of NMR and MS. The antimicrobial and cytotoxic activities of the fungal extracts and their delivered compounds were studied. This might be helpful for the cure of recent diseases, and drug-resistant phenomena as well as in the development of pharmaceutical, agrochemical and biochemical agents and their lead compounds. | ||
| Keywords | ||
| bioactive metabolites; biological activities; Endophytic; terrestrial fungi | ||
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