Bioactive lignans and other phenolics from the roots, leaves and seeds of L. grown in Egypt
Aboutabl, E., El Mahdy, M., Sokkar, N., Sleem, A., Shams, M. (2012). Bioactive lignans and other phenolics from the roots, leaves and seeds of L. grown in Egypt. EKB Journal Management System, 11(1), 59-65. doi: 10.7123/01.EPJ.0000415466.17860.6a
Elsayed A. Aboutabl; Mona E. El Mahdy; Nadia M. Sokkar; Amany A. Sleem; Manal M. Shams. "Bioactive lignans and other phenolics from the roots, leaves and seeds of L. grown in Egypt". EKB Journal Management System, 11, 1, 2012, 59-65. doi: 10.7123/01.EPJ.0000415466.17860.6a
Aboutabl, E., El Mahdy, M., Sokkar, N., Sleem, A., Shams, M. (2012). 'Bioactive lignans and other phenolics from the roots, leaves and seeds of L. grown in Egypt', EKB Journal Management System, 11(1), pp. 59-65. doi: 10.7123/01.EPJ.0000415466.17860.6a
Aboutabl, E., El Mahdy, M., Sokkar, N., Sleem, A., Shams, M. Bioactive lignans and other phenolics from the roots, leaves and seeds of L. grown in Egypt. EKB Journal Management System, 2012; 11(1): 59-65. doi: 10.7123/01.EPJ.0000415466.17860.6a

Bioactive lignans and other phenolics from the roots, leaves and seeds of L. grown in Egypt

Egyptian Pharmaceutical Journal
Volume 11, Issue 1, June 2012, Pages 59-65    PDF (467.62 K)
DOI: 10.7123/01.EPJ.0000415466.17860.6a
Authors
Elsayed A. Aboutabl; Mona E. El Mahdy; Nadia M. Sokkar; Amany A. Sleem; Manal M. Shams
Abstract
Aim
Investigation of the phenolic constituents of roots, leaves and seeds of L. cultivated in Egypt.
Methods
Qualitative and quantitative analysis of lignans and other phenolics by LC-MS/MS and HPLC/PDA-LC-MS/MS, as well as evaluation of potential bioactivities.
Results and conclusions
LC-MS/MS of the ethyl acetate fractions from seeds, leaves and roots showed the presence of 13 phenolics, including lignans, distributed in the different organs. The following phenolics were identified: caffeic acid , genistein , biochanin A , luteolin , chlorogenic acid , materisenol , arctigenin , quercetin , cynarin , arctiin , lappaol A , rutin and lappaol F . Quantification of these compounds by HPLC-PDA-MS/MS showed that arctiin was the major compound in seeds. The antioxidant, antihepatotoxic, anti-inflammatory and cytotoxic activities of ethanolic extracts of the different organs were evaluated.
Keywords
antihepatotoxicity; Anti-inflammatory; antioxidant; L; Coumarin; Cytotoxicity; lignans; Phenolics
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