D-dopaminergic receptor and 5-HT serotoninergic receptor antagonists having antiemetic profile | ||||
Egyptian Pharmaceutical Journal | ||||
Volume 12, Issue 1, June 2013, Page 1-10 PDF (960.78 K) | ||||
DOI: 10.7123/01.EPJ.0000428875.20180.de | ||||
![]() | ||||
Authors | ||||
Mohamed N. Aboul-Enein; Aida A. EL-Azzouny![]() | ||||
Abstract | ||||
Metoclopramide is the prototype of the orthopramide family and is used clinically as a stimulant of upper gastrointestinal motility and as an antiemetic. Its antiemetic potential is attributed mainly to the antagonist activity at D-dopaminergic receptors in the chemoreceptor trigger zone of the central nervous system. Besides, ondansetron was the first selective 5-HT serotoninergic receptor antagonist used in clinics as an antiemetic. Herein, the antiemetic profile of different chemical classes of D-dopaminergic receptor and 5-HT serotoninergic receptor antagonists will be discussed, which may be helpful in the development of potent antiemetic agents. | ||||
Keywords | ||||
antagonists; Antiemetic; D-dopaminergic receptor; 5-HT serotoninergic receptor | ||||
Statistics Article View: 48 PDF Download: 65 |
||||