D-dopaminergic receptor and 5-HT serotoninergic receptor antagonists having antiemetic profile
Aboul-Enein, M., EL-Azzouny, A., Maklad, Y., Attia, M., Abd EL-Hamid Ismail, M., Abd EL-Hamid, W. (2013). D-dopaminergic receptor and 5-HT serotoninergic receptor antagonists having antiemetic profile. EKB Journal Management System, 12(1), 1-10. doi: 10.7123/01.EPJ.0000428875.20180.de
Mohamed N. Aboul-Enein; Aida A. EL-Azzouny; Yousreya A. Maklad; Mohamed I. Attia; Mohamed Abd EL-Hamid Ismail; Walaa H.A. Abd EL-Hamid. "D-dopaminergic receptor and 5-HT serotoninergic receptor antagonists having antiemetic profile". EKB Journal Management System, 12, 1, 2013, 1-10. doi: 10.7123/01.EPJ.0000428875.20180.de
Aboul-Enein, M., EL-Azzouny, A., Maklad, Y., Attia, M., Abd EL-Hamid Ismail, M., Abd EL-Hamid, W. (2013). 'D-dopaminergic receptor and 5-HT serotoninergic receptor antagonists having antiemetic profile', EKB Journal Management System, 12(1), pp. 1-10. doi: 10.7123/01.EPJ.0000428875.20180.de
Aboul-Enein, M., EL-Azzouny, A., Maklad, Y., Attia, M., Abd EL-Hamid Ismail, M., Abd EL-Hamid, W. D-dopaminergic receptor and 5-HT serotoninergic receptor antagonists having antiemetic profile. EKB Journal Management System, 2013; 12(1): 1-10. doi: 10.7123/01.EPJ.0000428875.20180.de

D-dopaminergic receptor and 5-HT serotoninergic receptor antagonists having antiemetic profile

Egyptian Pharmaceutical Journal
Volume 12, Issue 1, June 2013, Pages 1-10    PDF (960.78 K)
DOI: 10.7123/01.EPJ.0000428875.20180.de
Authors
Mohamed N. Aboul-Enein; Aida A. EL-Azzouny; Yousreya A. Maklad; Mohamed I. Attia; Mohamed Abd EL-Hamid Ismail; Walaa H.A. Abd EL-Hamid
Abstract

Metoclopramide is the prototype of the orthopramide family and is used clinically as a stimulant of upper gastrointestinal motility and as an antiemetic. Its antiemetic potential is attributed mainly to the antagonist activity at D-dopaminergic receptors in the chemoreceptor trigger zone of the central nervous system. Besides, ondansetron was the first selective 5-HT serotoninergic receptor antagonist used in clinics as an antiemetic. Herein, the antiemetic profile of different chemical classes of D-dopaminergic receptor and 5-HT serotoninergic receptor antagonists will be discussed, which may be helpful in the development of potent antiemetic agents.
Keywords
antagonists; Antiemetic; D-dopaminergic receptor; 5-HT serotoninergic receptor
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