Desmutagenic and antimutagenic potential of phenolics from (C.DC.), | ||
| Egyptian Pharmaceutical Journal | ||
| Volume 12, Issue 2, July 2013, Pages 148-154 PDF (257.35 K) | ||
| DOI: 10.4103/1687-4315.124018 | ||
| Authors | ||
| Fatma A. Hashem; Elsayed A. Aboutabl; Sahar S. EL Souda; Maysa Moharam; Amal A. Mammoun; Manal Shabana | ||
| Abstract | ||
| Background and objectives Antimutagenic or protective effects have been attributed to many classes of phytocompounds, mainly flavonoids and phenolic compounds, present in foods. Anticancer, antioxidant and anti-inflammatory activities of spp. have been reported, but their desmutagenic and antimutagenic activities were not studied. The aim of this study was to identify the phenolic contents of and correlate the desmutagenic and antimutagenic activities of these compounds. Materials and methods Desmutagenic and antimutagenic activities of specimen extracts of leaves and flowers were evaluated by measuring the inhibition of TA100 His revertants induced by ethyl methanesulphonate and ribose lysine. The phenolic contents of leaf extracts were determined using column and paper chromatography. Spectroscopic analysis UV, H NMR, C NMR and electrospray ionization were applied to identify the isolated compounds. Results and conclusion Five phenolic compounds were isolated for the first time from leaves. These compounds were identified as quercetin 3--rhamnoglucoside (rutin), quercetin 3--rhamnoside, quercetin 3--glucoside, quercetin and 6-methoxycoumarin-7- arabinofuranoside. The alcoholic extracts of both leaves and flowers (total and successive) of , rutin and quercetin rhamnoside isolated from the leaves, exhibited desmutagenic and antimutagenic activity against ethyl methanesulphonate-induced and ribose lysine-induced reversion. | ||
| Keywords | ||
| ethyl methanesulphonate; ribose lysine; Rutin; TA100 (His); scopoletin 7--α-arabinofuranoside | ||
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