Phytoconstituents from L. aqueous ethanol extract and its immunomodulatory effect on diabetic infected rats | ||
| Egyptian Pharmaceutical Journal | ||
| Volume 14, Issue 1, January 2015, Pages 36-43 PDF (284.14 K) | ||
| DOI: 10.4103/1687-4315.154713 | ||
| Authors | ||
| Manal H. Shabana; Eman M. Shahy; Mona M. Taha; Gehan M. Mahdy; Maha H. Mahmoud | ||
| Abstract | ||
| Background and objectives L. () has been shown to possess a wide variety of pharmacological properties against malignant proliferation, inflammation, and parasitosis. Further, has been reported to possess antioxidant and hypoglycemic activities. Materials and methods The extraction and isolation of the constituents of were performed according to the standard methods of column, paper, and thin-layer chromatography. The chemical structure of the isolated compounds was established by R, by characterization of acid hydrolysates, by ultraviolet spectral analysis, and by H-NMR spectroscopy. Serum glucose, immunoglobulin E (IgE), nitric oxide, cytokine levels (IL-6, TNF-α, and IL-1β), and blood cell counts (total and differential) were determined. Results and conclusion Three compounds were isolated from the alcohol extract of . These compounds were identified as apigenin 7--rhamnoside 4′--glucoside, a new compound isolated for the first time from nature, and 7-methoxyapigenin-6--glucoside and -(3-methoxyphenyl) acetamide, two known compounds isolated from for the first time. Also, the alcohol extract of ameliorated the serum glucose, IgE, nitric oxide, and cytokine levels in diabetic infected rats with . | ||
| Keywords | ||
| Apigenin-7-O-rhamnoside- 4′--glucoside; phytoconstituents; hypoglycemic and immunomodulatory activities; diabetic rats; “ aureus” infection; Cytokines; IgE; Nitric oxide; blood counts | ||
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