Pharmacological evaluation of (Linn.) on bronchial asthma | ||||
| Egyptian Pharmaceutical Journal | ||||
| Volume 15, Issue 1, January 2016, Page 25-30 PDF (407 K) | ||||
| DOI: 10.4103/1687-4315.184030 | ||||
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| Authors | ||||
| Ganesh Patro; Madhulata Panda; Prativa Das; Amrita Bhaiji; Avinash Panda; Himanshu Bhusan Sahoo | ||||
| Abstract | ||||
| Objective The present study was conducted to investigate the antiasthmatic potential from the flowers of Linn. to validate its traditional claims. Materials and methods The antiasthmatic activity of the hydroalcoholic extract of flower (HMPF) was evaluated by studying histamine or acetylcholine-induced bronchospasm in guinea pigs, compound 48/80-induced mast cell degranulation in albino rats, and histamine-induced constriction in isolated guinea pig trachea. The preconvulsion dyspnea time at the 0th and seventh day at a dose of 200 and 400 mg/kg in guinea pigs, the percentage of granulated and degranulated mast cells at doses of 500, 750, and 1000 μg/ml in rats, and muscular contraction at doses of 500, 750, and 1000 μg/ml in isolated guinea pig trachea were evaluated and compared with their respective control groups. Results Phytochemical studies revealed the presence of flavonoids, steroids, saponin, terpenoids, lignins, and phenolic compounds in the extract. In addition, treatment with HMPF significantly ( < 0.001) decreased the bronchospasm induced by histamine or acetylcholine in guinea pigs, the degranulation of mast cell in rats, and histamine-induced constriction in isolated guinea pig trachea, when compared with the inducer group. In addition, HMPF showed a dose-dependent antiasthmatic effect in the animals. Conclusion The present study concluded that the antiasthmatic activity of the HMPF may be due to the presence of the above-mentioned phytoconstituents causing membrane stabilization, suppression of antibody production, and inhibition of antigen-induced histamine and acetylcholine. | ||||
| Keywords | ||||
| Asthma; bronchospasm; histamine; mast cell degranulation | ||||
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