Cytotoxic activity of ketorolac-loaded chitosan nanoparticles in SCC-29 cell lines
Venu, K., Mondal, S., Mondal, P. (2018). Cytotoxic activity of ketorolac-loaded chitosan nanoparticles in SCC-29 cell lines. EKB Journal Management System, 17(1), 53-59. doi: 10.4103/epj.epj_1_18
Kola Venu; Sumanta Mondal; Prasenjit Mondal. "Cytotoxic activity of ketorolac-loaded chitosan nanoparticles in SCC-29 cell lines". EKB Journal Management System, 17, 1, 2018, 53-59. doi: 10.4103/epj.epj_1_18
Venu, K., Mondal, S., Mondal, P. (2018). 'Cytotoxic activity of ketorolac-loaded chitosan nanoparticles in SCC-29 cell lines', EKB Journal Management System, 17(1), pp. 53-59. doi: 10.4103/epj.epj_1_18
Venu, K., Mondal, S., Mondal, P. Cytotoxic activity of ketorolac-loaded chitosan nanoparticles in SCC-29 cell lines. EKB Journal Management System, 2018; 17(1): 53-59. doi: 10.4103/epj.epj_1_18

Cytotoxic activity of ketorolac-loaded chitosan nanoparticles in SCC-29 cell lines

Egyptian Pharmaceutical Journal
Volume 17, Issue 1, January 2018, Page 53-59  XML PDF (1.75 MB)
DOI: 10.4103/epj.epj_1_18
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Authors
Kola Venu; Sumanta Mondalorcid ; Prasenjit Mondal
Abstract
Context
Ketorolac (KT) is a NSAID, with multiple pharmacological activities having been reported.
Aim
To formulate chitosan nanoparticles of KT for assessing their potential in decreasing the growth of colon cancer cells.
Materials and methods
Chitosan nanoparticles of KT such as F1 and F2 have shown anticancer activity against SCC-29 cell lines. Furthermore, nanoparticles have been subjected to stability test at various pH, drug-release study, and in-vivo pharmacokinetics in Wistar rats.
Results
The nanoparticles were in the size range between 164 and 210 nm. The oral absorption of nanoparticles was relatively higher than the KT alone.
Conclusion
The prepared nanoparticle formulations showed better activity than KT alone.
Keywords
Chitosan; Cytotoxicity; dug stability; Ketorolac; Nanoparticles
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