Synthesis and biological activity of some new fused pyrazole-c-nucleosides
El-Assaly, S., Ismail, A., Sobaih, S., El-Naggar, T. (2018). Synthesis and biological activity of some new fused pyrazole-c-nucleosides. EKB Journal Management System, 17(2), 104-108. doi: 10.4103/epj.epj_4_18
Samy A. El-Assaly; Abdel-Hameed A. Ismail; Sahr A. Sobaih; Tarek B. El-Naggar. "Synthesis and biological activity of some new fused pyrazole-c-nucleosides". EKB Journal Management System, 17, 2, 2018, 104-108. doi: 10.4103/epj.epj_4_18
El-Assaly, S., Ismail, A., Sobaih, S., El-Naggar, T. (2018). 'Synthesis and biological activity of some new fused pyrazole-c-nucleosides', EKB Journal Management System, 17(2), pp. 104-108. doi: 10.4103/epj.epj_4_18
El-Assaly, S., Ismail, A., Sobaih, S., El-Naggar, T. Synthesis and biological activity of some new fused pyrazole-c-nucleosides. EKB Journal Management System, 2018; 17(2): 104-108. doi: 10.4103/epj.epj_4_18

Synthesis and biological activity of some new fused pyrazole-c-nucleosides

Egyptian Pharmaceutical Journal
Volume 17, Issue 2, May 2018, Page 104-108  XML PDF (156.63 K)
DOI: 10.4103/epj.epj_4_18
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Authors
Samy A. El-Assaly; Abdel-Hameed A. Ismail; Sahr A. Sobaih; Tarek B. El-Naggar
Abstract
Background and objectives
Owing to the high antiviral, antibiotic, antitumor, and antifungal activities associated with various C-nucleosides, much attention has been paid on the synthesis of this class of compounds. We synthesized new pyrazole-C-nucleosides through one-pot reaction of open sugar, phenyl hydrazine hydrochloride, and different bases in presence of acetic acid and sodium acetate as a catalyst. These nucleosides, containing pyrazole moiety, have been marked as biologically active compounds.
Keywords
chemotherapeutic effects; One-pot synthesis; pyrazole-C-nucleosides
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