Insights into the in-vitro hypocholesterolemic, antioxidant, antirotavirus, and anticolon cancer activities of the methanolic extracts of a Japanese lichen, , and a Japanese mushroom,
Elkhateeb, W., Daba, G., El-Dein, A., Sheir, D., Fayad, W., Shaheen, M., Elmahdy, E., Wen, T. (2020). Insights into the in-vitro hypocholesterolemic, antioxidant, antirotavirus, and anticolon cancer activities of the methanolic extracts of a Japanese lichen, , and a Japanese mushroom,. EKB Journal Management System, 19(1), 67-73. doi: 10.4103/epj.epj_56_19
Waill A. Elkhateeb; Ghoson M. Daba; Asmaa N. El-Dein; Donia H. Sheir; Walid Fayad; Mohamed N. Shaheen; ELmahdy M. Elmahdy; Ting-Chi Wen. "Insights into the in-vitro hypocholesterolemic, antioxidant, antirotavirus, and anticolon cancer activities of the methanolic extracts of a Japanese lichen, , and a Japanese mushroom,". EKB Journal Management System, 19, 1, 2020, 67-73. doi: 10.4103/epj.epj_56_19
Elkhateeb, W., Daba, G., El-Dein, A., Sheir, D., Fayad, W., Shaheen, M., Elmahdy, E., Wen, T. (2020). 'Insights into the in-vitro hypocholesterolemic, antioxidant, antirotavirus, and anticolon cancer activities of the methanolic extracts of a Japanese lichen, , and a Japanese mushroom,', EKB Journal Management System, 19(1), pp. 67-73. doi: 10.4103/epj.epj_56_19
Elkhateeb, W., Daba, G., El-Dein, A., Sheir, D., Fayad, W., Shaheen, M., Elmahdy, E., Wen, T. Insights into the in-vitro hypocholesterolemic, antioxidant, antirotavirus, and anticolon cancer activities of the methanolic extracts of a Japanese lichen, , and a Japanese mushroom,. EKB Journal Management System, 2020; 19(1): 67-73. doi: 10.4103/epj.epj_56_19

Insights into the in-vitro hypocholesterolemic, antioxidant, antirotavirus, and anticolon cancer activities of the methanolic extracts of a Japanese lichen, , and a Japanese mushroom,

Egyptian Pharmaceutical Journal
Volume 19, Issue 1, January 2020, Page 67-73  XML PDF (211.89 K)
DOI: 10.4103/epj.epj_56_19
View on SCiNiTO View on SCiNiTO
Authors
Waill A. Elkhateeb; Ghoson M. Daba; Asmaa N. El-Dein; Donia H. Sheir; Walid Fayadorcid ; Mohamed N. Shaheen; ELmahdy M. Elmahdy; Ting-Chi Wen
Abstract
Background and objective
Medicinal mushrooms, as well as lichens are potential sources of bioactive compounds against many lethal diseases. Therefore, in-vitro evaluations of the biological activities of the 80% methanolic extracts of two Japanese originated samples, namely, the mushroom , and the lichen have been performed.
Materials and methods
Extraction of and was conducted using 80% methanol. The resulted extracts were examined for their in-vitro hypocholesterolemic and antirotavirus activities, as well as antihuman colon cancer action.
Results and conclusion
It was revealed that both extracts have potent hypocholesterolemic effects. in concentration of 24 mg/ml could successfully reduce the cholesterol concentration to 100±0% after 96 h of incubation at room temperature, whereas reaching this degree of reduction in cholesterol concentration required using 32 mg/ml of extract. On the contrary, the extract of at concentration of 1.0 mg/ml exhibited a stronger DPPH scavenging activity (99.5±0.166%), in comparison with 66.24±0.43% in case of using the same concentration of the extract. extract showed antirotavirus in a therapeutic index of 11, whereas extract recorded 3.4 only. The antihuman colon cancer study elucidated that both extracts have a moderate activity toward HCT116 human colon carcinoma. extract achieved a cytotoxicity of 57.90±4.4%, whereas the extract of displayed only 43.10±0.9%. Studies on and introduce them as promising sources of biologically potent compounds that can be candidates for use in treatment of many diseases after further studies.
Keywords
Biological Activity; Crude extract; HCT116 human colon carcinoma cell line; hypocholesterolemic; rotavirus SA-11
Statistics
Article View: 58
PDF Download: 30