Co-milling of oxcarbazepine with Soluplus for the enhancement of solubility and dissolution rate | ||
| Egyptian Pharmaceutical Journal | ||
| Volume 19, Issue 3, July 2020, Pages 291-296 PDF (410.91 K) | ||
| DOI: 10.4103/epj.epj_27_20 | ||
| Authors | ||
| Amjad Hussain; Muhammad S. Arshad; Sidra Noreen; Javaria Khalid; Nasir Abbas; Jahanzeb Mudassir | ||
| Abstract | ||
| Background and objective Poor solubility and dissolution rates affect the bioavailability of drugs. The aim of this study was to improve the solubility and dissolution rate of a poorly soluble drug, oxcarbazepine by its mechanochemical activation via the co-milling technique. Materials and methods The drug and Soluplus (in two different ratios) were co-milled in a planetary ball bill. The bulk properties, solubility, and dissolution rate were determined and differential scanning calorimetry, powder X-ray diffraction, Fourier-transform infrared spectroscopy (FTIR), and laser diffraction (for particle size determination) techniques were used to characterize drug and co-milled formulations. Results and discussion The results have shown good compressibility and excellent flow of co-milled mixtures as compared with the drug. The solubility of the drug (0.448±2 mg/ml) was increased by 2–3-fold in co-milled mixtures while the dissolution rate of oxcarbazepine was increased up to 2.5–3 times. Both differential scanning calorimetry and powder X-ray diffraction results have shown a reduction of crystallinity while the Fourier-transform infrared spectroscopy spectra indicated no interaction. Laser diffraction studies have shown ∼5 times reduction in mean particle size. Conclusion The study concludes that co-milling is effective in enhancing solubility and dissolution of poor soluble drugs. | ||
| Keywords | ||
| Ball mill; Crystallinity; Mechanochemical Activation; Particle size | ||
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