Insights on the inhibitors of dipeptidyl peptidase 1 as mast-cell stabilizer
El-Feki, G., EL-Desouky, M., Badway, M. (2021). Insights on the inhibitors of dipeptidyl peptidase 1 as mast-cell stabilizer. EKB Journal Management System, 20(4), 264-269. doi: 10.4103/epj.epj_50_21
Ghada M. El-Feki; Mohamed A. EL-Desouky; Mohamed A. Badway. "Insights on the inhibitors of dipeptidyl peptidase 1 as mast-cell stabilizer". EKB Journal Management System, 20, 4, 2021, 264-269. doi: 10.4103/epj.epj_50_21
El-Feki, G., EL-Desouky, M., Badway, M. (2021). 'Insights on the inhibitors of dipeptidyl peptidase 1 as mast-cell stabilizer', EKB Journal Management System, 20(4), pp. 264-269. doi: 10.4103/epj.epj_50_21
El-Feki, G., EL-Desouky, M., Badway, M. Insights on the inhibitors of dipeptidyl peptidase 1 as mast-cell stabilizer. EKB Journal Management System, 2021; 20(4): 264-269. doi: 10.4103/epj.epj_50_21

Insights on the inhibitors of dipeptidyl peptidase 1 as mast-cell stabilizer

Egyptian Pharmaceutical Journal
Volume 20, Issue 4, October 2021, Pages 264-269    PDF (164.57 K)
DOI: 10.4103/epj.epj_50_21
Authors
Ghada M. El-Feki; Mohamed A. EL-Desouky; Mohamed A. Badway
Abstract


Tryptase and chymase are potent proteases secreted by mast cells upon activation. These abundant mast-cell proteases are converted into catalytically active forms by dipeptidyl peptidase 1 (DPP1). DPP1 is one of the most important components to initiate chain reaction for triggering the inflammatory response mediating allergic diseases such as asthma and allergic rhinitis. DPP1 can remove the safety catch on various mast-cell proteases, including tryptase and chymase, and plays an essential role in controlling their activity. However, the exact role of DPP1 in mast-cell degranulation is still not fully recognized.
Keywords
dipeptidyl peptidase 1; inhibitors of mast cell; mast-cell-stabilizing compounds
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