Protective efficiency of on diet-induced nonalcoholic fatty liver disease in rats using the urinary lipidomics approach | ||
| Egyptian Pharmaceutical Journal | ||
| Volume 20, Issue 4, October 2021, Pages 339-351 PDF (5.84 M) | ||
| DOI: 10.4103/epj.epj_40_21 | ||
| Authors | ||
| Noha S. Hussein; Azza S. Helmy; Naglaa M. Sherif; Hassan Z. Ghanem; Abdel N. El Gendy; Abdel-Hamid Z. Abdel-Hamid | ||
| Abstract | ||
| Background Nonalcoholic fatty liver disease (NAFLD) is currently one of the leading causes of chronic liver disease in western countries and is characterized by excessive fat deposition in the liver. It affects 15–30% of the general population worldwide. Objectives This study aims to detect and evaluate a reproducible signature of lipid metabolome for early detection of NAFLD as well as protective efficiency of based on targeted metabolomics analysis of urine. Results and conclusion A discrete divergence in levels of glycerol, myristic acid, cholesterol, 1,3-dipalmitin, and oleic acid was recorded in urine of rats bearing NAFLD in contrast to healthy ones. These metabolites were considered as diagnostic metabolic biomarkers for NAFLD. This study showed that these metabolites were less affected in rats given as a protective agent. It is concluded from this research that the lipidomic approach could be used for early diagnosis of NAFLD in urine as well as assessment of the stratification of protection by herbal medication. | ||
| Keywords | ||
| biomarkers; lipidomics; Nonalcoholic fatty liver disease | ||
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