Anticancer and antibacterial potentials of methanolic extracts of the leaf and stem bark of
Oni, M., Bello, O., Ademola, R., Mba, U., Oni, V. (2022). Anticancer and antibacterial potentials of methanolic extracts of the leaf and stem bark of. EKB Journal Management System, 21(1), 40-45. doi: 10.4103/epj.epj_47_21
Mathew O. Oni; Olorunjuwon O. Bello; Rachael A. Ademola; Uchechi D. Mba; Vincent O. Oni. "Anticancer and antibacterial potentials of methanolic extracts of the leaf and stem bark of". EKB Journal Management System, 21, 1, 2022, 40-45. doi: 10.4103/epj.epj_47_21
Oni, M., Bello, O., Ademola, R., Mba, U., Oni, V. (2022). 'Anticancer and antibacterial potentials of methanolic extracts of the leaf and stem bark of', EKB Journal Management System, 21(1), pp. 40-45. doi: 10.4103/epj.epj_47_21
Oni, M., Bello, O., Ademola, R., Mba, U., Oni, V. Anticancer and antibacterial potentials of methanolic extracts of the leaf and stem bark of. EKB Journal Management System, 2022; 21(1): 40-45. doi: 10.4103/epj.epj_47_21

Anticancer and antibacterial potentials of methanolic extracts of the leaf and stem bark of

Egyptian Pharmaceutical Journal
Volume 21, Issue 1, January 2022, Page 40-45  XML PDF (114.44 K)
DOI: 10.4103/epj.epj_47_21
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Authors
Mathew O. Oni; Olorunjuwon O. Belloorcid ; Rachael A. Ademola; Uchechi D. Mba; Vincent O. Oni
Abstract
Context

is one of the most important woody fodder plants in many parts of Africa.
Aims
This study evaluated the anticancer and antibacterial potentials of leaf and stem bark in Nigeria.
Patients and methods
The methanolic extracts were filtered and concentrated according to standard procedures. The extracts were screened for phytochemical properties in accordance with standard methods. The antibacterial potentials of the plant extracts against 10 selected clinical bacterial isolates were evaluated using the agar well diffusion method. Anticancer potential using Human Embryonic Kidney cells and therapeutic index (TI) of the plant extracts were determined by standard procedures.
Statistical analysis used
The test was used to determine the correlation between the antibacterial activities exerted by different concentrations of the stem bark and leaf extracts.
Results
Both plant parts contained alkaloids, anthraquinones, flavonoids, glycosides, saponins, tannins, triterpenes, and xanthoproteins. The anticancer test with Human Embryonic Kidney cells showed that the leaf and stem bark extracts elicited cytotoxic activity. The leaf extract had TI ranging from 0.23 to 0.97 whereas that of the stem bark ranged from 0.24 to 0.75, against the selected test organisms. There was no significant difference (=0.077) in the TI between the leaf and the stem bark extracts. There were no significant differences between the antibacterial activities exerted by the leaf and stem bark extracts and within the antibacterial activities exerted by the control antibiotics (=0.073).
Conclusions
This study revealed that the stem bark and leaf extracts of possess anticancer and antibacterial properties.
Keywords
Afzelia africana; antibiotics; Anticancer; Fabaceae; phytochemicals; therapeutic index
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