Ketamine induces schizophrenia-like condition in rats via amendment of neurotransmitters and behavior
Georgy, G., Gad, A., Anwar, H., Taha, R., Hassan, A. (2023). Ketamine induces schizophrenia-like condition in rats via amendment of neurotransmitters and behavior. EKB Journal Management System, 22(1), 30-37. doi: 10.4103/epj.epj_61_22
Gehan S. Georgy; Amany M. Gad; Hend Mohamed Anwar; Rehab H. Taha; Aliaa A. Hassan. "Ketamine induces schizophrenia-like condition in rats via amendment of neurotransmitters and behavior". EKB Journal Management System, 22, 1, 2023, 30-37. doi: 10.4103/epj.epj_61_22
Georgy, G., Gad, A., Anwar, H., Taha, R., Hassan, A. (2023). 'Ketamine induces schizophrenia-like condition in rats via amendment of neurotransmitters and behavior', EKB Journal Management System, 22(1), pp. 30-37. doi: 10.4103/epj.epj_61_22
Georgy, G., Gad, A., Anwar, H., Taha, R., Hassan, A. Ketamine induces schizophrenia-like condition in rats via amendment of neurotransmitters and behavior. EKB Journal Management System, 2023; 22(1): 30-37. doi: 10.4103/epj.epj_61_22

Ketamine induces schizophrenia-like condition in rats via amendment of neurotransmitters and behavior

Egyptian Pharmaceutical Journal
Volume 22, Issue 1, January 2023, Page 30-37  XML PDF (3.9 MB)
DOI: 10.4103/epj.epj_61_22
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Authors
Gehan S. Georgy; Amany M. Gad; Hend Mohamed Anwarorcid ; Rehab H. Taha; Aliaa A. Hassan
Abstract
Background
The pupae of mulberry silkworms, family Bombycidae, possess a great number of proteins that cover all of the necessary amino acids obligatory for well-being.
Objective
In this study, we aimed to evaluate the probable antipsychotic effect of pupae of mulberry silkworms in a rat model of schizophrenia prompted by ketamine on the cerebral cortex, hippocampus, and striatum, the brain areas involved in neuropsychiatric complaints.
Materials and methods
To this end, male albino rats were classified as follows: group 1 was the control group; group 2 animals were administered 135 mg/kg, p.o. silkworm pupae for 3 weeks; group 3 animals received vehicle for 3 weeks, and ketamine (30 mg/kg, i.p.) for the last 5 consecutive days of the experiment; and group 4 was the silkworm pupae and ketamine-treated group.
Results
The results revealed that treatment with silkworm pupae improved the exploration of schizophrenic rats in the novel object test and almost normalized their locomotor activity in the open field test. Additionally, silkworm pupae modulated the content of catecholamines and oxidative state in the cerebral cortex, hippocampus, and striatum of schizophrenic rats; however, the acetylcholine esterase activity was restored in the hippocampus only. Histopathological damages caused by ketamine are partially reduced by silkworm pupae.
Conclusion
Our data suggest that silkworm pupae, via neurobehavioral modulatory pathway, exhibit beneficial effects against psychomimetic influence of ketamine.
Keywords
Ketamine; neurotransmitters; novel object; open field; Oxidative Stress; Schizophrenia; silkworm pupae
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