Association of waist circumference, serum ghrelin level and insulin resistance in polycystic ovary syndrome: a cross-sectional study | ||
| Egyptian Pharmaceutical Journal | ||
| Volume 22, Issue 4, October 2023, Pages 551-556 PDF (1.24 M) | ||
| Authors | ||
| Madhur M. Gupta; Chaitanya V. Bhojane; Sonali B. Rode; Harsh V. Salankar | ||
| Abstract | ||
| Context Ghrelin is mostly secreted by enteroendocrine cells of stomach. It is responsible for appetite, carbohydrate metabolism, and improving muscle mass and bone density. Ghrelin also plays a perilous part in reproductive and energy-related activities. In the recent past, Polycystic ovary syndrome (PCOS) is a key root of infertility due to abnormal hormonal activities. Insulin resistance (IR) is more common in PCOS. Aims To find the connection between waist circumference, serum ghrelin concentrations, and insulin resistance in PCOS patients. Settings and design A cross-sectional study was carried out at a tertiary care teaching hospital. Materials and methods Patients within the range of 20–35 years of age group and suffering from PCOS were recruited from Gynaecology OPD. The waist circumference was measured in centimeters. 5 ml fasting blood sample was collected and analyzed for − Plasma Ghrelin, Plasma glucose, Plasma Insulin, and Insulin resistance by HOMA-IR score. Statistical analysis used SPSS version 26 was utilized. Data of the measured variables were entered in the Excel sheet and expressed as mean ± standard deviation. Co-efficient of correlation denoted the relation between the variables. Results We analysed the waist circumference, serum ghrelin, plasma insulin level and HOMA-IR score of the subjects. Waist circumference was positively correlated with HOMA-IR and serum ghrelin level. Serum ghrelin and insulin resistance also showed a strong association. Conclusions Results obtained from our study state that in PCOS patients waist circumference is directly proportional to serum ghrelin level and insulin resistance. Also, serum ghrelin has a correlation with insulin resistance. | ||
| Keywords | ||
| Keywords; Homeostatic model assessment; Insulin Resistance; polycystic ovary syndrome; serum ghrelin; waist circumference | ||
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