Effect of Social Overcrowding and Isolation Stress on Alloxan-Induced Diabetic Male Albino Rats | ||
| International Journal of Medical Arts | ||
| Article 14, Volume 7, Issue 2, February 2025, Pages 5415-5421 PDF (2.06 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ijma.2025.344653.2081 | ||
| Authors | ||
| Nora El-Saeed Mansour* 1; Mohammad Adel Shalaby Abd El-Latif2; Mohammad Ebraheem Aref3; Mohammad Othman El-Sayed Zarad2; Albayoumi Ali Bayoumi Fouda2 | ||
| 1Department of Physiology, Damietta Faculty of Medicine, Al-Azhar University, Damietta, Egypt. | ||
| 2Department of Medical physiology, Faculty of Medicine, Al-Azhar University, Cairo, Egypt. | ||
| 3Department of Clinical pathology, Faculty of Medicine, Al-Azhar University, Cairo, Egypt. | ||
| Abstract | ||
| Background: Crowding, social isolation, and a lack of social support negatively impact health and are significant contributors to human illnesses. Aim of the work: The study aimed to assess the potential impacts of social crowding or isolation on male albino rats with diabetes caused by alloxan. Patients and methods: Ninety-six adult male albino rats of the local strain were selected. They were split into six groups: the control normal group, isolated group, overcrowded group, diabetic group, isolated diabetic group, and overcrowded diabetic group. At the end, serum fasting blood glucose, insulin level, AST, ALT, albumin, GH, ACTH, and cortisol were estimated. Animal body weight and food intake were also measured. Slices of the liver and pancreas were acquired for histopathological analysis. Results: In rats with alloxan-induced diabetes, crowding or isolation caused the disease to worsen. This included changes in body weight and food intake, significant cellular alterations on histopathological analysis, and more disrupted glucose metabolism, serum insulin, liver functions, serum growth hormone, serum cortisol, and ACTH. Conclusion: Crowding and Social Isolation had harmful effects on diabetes. Thus, stress relieve must be a standard item in the treatment or prevention of diabetes mellitus. | ||
| Keywords | ||
| Diabetes; Stress; Alloxan; Social Isolation; Social Overcrowding | ||
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