Evaluating Immunohistochemical Expression of Junctional Adhesion Molecule - A (JAM- A) In Multiple Myeloma
I. Elshawarby, Z., Y. Bassyoni, O., S. El Ashry, M., Salama, A., A. Agina, H., E. Soliman, A. (2025). Evaluating Immunohistochemical Expression of Junctional Adhesion Molecule - A (JAM- A) In Multiple Myeloma. EKB Journal Management System, (), -. doi: 10.21608/bmfj.2025.346695.2300
Zeinab I. Elshawarby; Omneya Y. Bassyoni; Mona S. El Ashry; Aya Ibrahim Salama; Hala A. Agina; Amira E. Soliman. "Evaluating Immunohistochemical Expression of Junctional Adhesion Molecule - A (JAM- A) In Multiple Myeloma". EKB Journal Management System, , , 2025, -. doi: 10.21608/bmfj.2025.346695.2300
I. Elshawarby, Z., Y. Bassyoni, O., S. El Ashry, M., Salama, A., A. Agina, H., E. Soliman, A. (2025). 'Evaluating Immunohistochemical Expression of Junctional Adhesion Molecule - A (JAM- A) In Multiple Myeloma', EKB Journal Management System, (), pp. -. doi: 10.21608/bmfj.2025.346695.2300
I. Elshawarby, Z., Y. Bassyoni, O., S. El Ashry, M., Salama, A., A. Agina, H., E. Soliman, A. Evaluating Immunohistochemical Expression of Junctional Adhesion Molecule - A (JAM- A) In Multiple Myeloma. EKB Journal Management System, 2025; (): -. doi: 10.21608/bmfj.2025.346695.2300

Evaluating Immunohistochemical Expression of Junctional Adhesion Molecule - A (JAM- A) In Multiple Myeloma

Benha Medical Journal
Articles in Press, Accepted Manuscript, Available Online from 29 January 2025  XML PDF (1.94 MB)
Document Type: Original Article
DOI: 10.21608/bmfj.2025.346695.2300
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Authors
Zeinab I. Elshawarby1; Omneya Y. Bassyoni2; Mona S. El Ashry3; Aya Ibrahim Salama email 4; Hala A. Agina5; Amira E. Soliman1
1Lecturer of Pathology, Faculty of Medicine, Benha University, Benha, Egypt
2Assistant Professor of Pathology, Faculty of Medicine, Benha University, Benha, Egypt
3Lecturer of Clinical Pathology, National Cancer Institute, Cairo University, Cairo, Egypt
4(M., B., B.CH), Demonstrator of Pathology, Faculty of Medicine, Benha University
5Professor of Pathology, Faculty of Medicine, Benha University, Benha, Egypt
Abstract
Background: 1% of all cancers and about 10% of all haematologic malignancies are multiple myeloma (MM). In various human cancers, including multiple myeloma, abnormal expression or deregulation of JAM-A, which controls cell growth and differentiation, results in a more aggressive phenotype and poor prognosis. Aim: to evaluate the immunohistochemical expression of JAM-A in cases of multiple myeloma and correlate its expression with variable clinicopathological parameters to assess its possible diagnostic and prognostic role and hence therapeutic modalities. Material and method: This is a selected retrospective immunohistochemical study of JAM-A performed on 40 cases of MM. Results: There is a statistically significant direct correlation between JAM-A overexpression and older Age (P= .022), histological type (immature & plasmablastic)(P=.020), diffuse pattern of infiltration(P=.016), increased BMB cellularity(P=.017), higher ISS Stage (P=.033), advanced R- ISS Stage (P=.042), No Complete response(P=.008), more Resistance to therapy (P= .032), Karyotyping result (P=.019), short survival (P= .014). Conclusion: JAM-A overexpression might have an important role in proliferation, invasion, progression, poor outcome of multiple myeloma cases. So, JAM-A might have a promising value in treatment of MM.
Keywords
Immunohistochemical; Junctional Adhesion Molecule – A; Multiple myeloma
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