Exosomes and Head and Neck Cancers: Can They Be Connected?
Hanafy, A., Mahmoud, M., Morkos, A., Emad, D., Hafed, L., Soliman, A., Al Bahrawey, S., Ibrahim, S. (2025). Exosomes and Head and Neck Cancers: Can They Be Connected?. EKB Journal Management System, 4(1), 2210-2222. doi: 10.21608/erurj.2025.290892.1146
Ahmed Hanafy; Momen Mohammed Mahmoud; Abanoub Morkos; Dina Emad; Layla Hafed; Aliaa Shaban Soliman; Sherif Al Bahrawey; Sally Ibrahim. "Exosomes and Head and Neck Cancers: Can They Be Connected?". EKB Journal Management System, 4, 1, 2025, 2210-2222. doi: 10.21608/erurj.2025.290892.1146
Hanafy, A., Mahmoud, M., Morkos, A., Emad, D., Hafed, L., Soliman, A., Al Bahrawey, S., Ibrahim, S. (2025). 'Exosomes and Head and Neck Cancers: Can They Be Connected?', EKB Journal Management System, 4(1), pp. 2210-2222. doi: 10.21608/erurj.2025.290892.1146
Hanafy, A., Mahmoud, M., Morkos, A., Emad, D., Hafed, L., Soliman, A., Al Bahrawey, S., Ibrahim, S. Exosomes and Head and Neck Cancers: Can They Be Connected?. EKB Journal Management System, 2025; 4(1): 2210-2222. doi: 10.21608/erurj.2025.290892.1146

Exosomes and Head and Neck Cancers: Can They Be Connected?

ERU Research Journal
Volume 4, Issue 1, January 2025, Page 2210-2222  XML PDF (234.15 K)
Document Type: Review article
DOI: 10.21608/erurj.2025.290892.1146
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Authors
Ahmed Hanafy email orcid 1; Momen Mohammed Mahmoudorcid 1; Abanoub Morkos2; Dina Emad3; Layla Hafedorcid 4; Aliaa Shaban Soliman3; Sherif Al Bahraweyorcid 1; Sally Ibrahim5
1Oral biology Department , Faculty of dentistry, Egyptian Russian University , Cairo , Egypt.
2Oral and Maxillofacial Surgery Department, Faculty of Dentistry, Beni-Suef University, Beni-Suef, Egypt
3Oral and maxillofacial surgery, faculty of dentistry, fayoum University.
4Assistant Professor of Oral and Maxillofacial Pathology, Faculty of Dentistry, Saba University, Sana’a, Yemen
5associate professor of oral and maxillofacial pathology, faculty of dentistry, Fayoum university, Egypt
Abstract
Introduction: Exosomes are extracellular microvesicles which are bound by a membrane , tiny, and have endocytic origins. Exosomes range in size from 30 to 150 nm and are rich in bioactive substances like metabolites, proteins, lipids, and nucleic acids. Review of literature: Exosomal miRNAs have the potential to serve as diagnostic biomarkers for a variety of malignancies, immunological responses, cell proliferation, tumor metastasis, tumor growth, and cell apoptosis. Exosomes have been connected to cancer progression, viral pathogenicity, immunological responses, and illnesses of the central nervous system. Exosome's properties are influenced by their lipid and protein content, and exosome's natural makeup may help them be more bioavailable and have fewer negative consequences. Conclusion: Exosomes are strongly associated to cancer diagnosis, tumor growth/metastasis and treatment of different head and neck cancers. Recommendations: multicomponent analysis of exosomes may be carried out for better understanding of their role in cancer progression and treatment response.
Keywords
Extracellular vesicles; tumors; biomarkers; miRNAs; drug delivery
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