Associations of Single Nucleotide Polymorphism (MMP-9 -1562 C/T rs 3918242) with the Risk of Severity in Adult Multiple Trauma ICU Admitted Patients: A Pilot Study
Aboelroos, S., Abotaqia, A., Azab, H., Hassan, N. (2025). Associations of Single Nucleotide Polymorphism (MMP-9 -1562 C/T rs 3918242) with the Risk of Severity in Adult Multiple Trauma ICU Admitted Patients: A Pilot Study. EKB Journal Management System, 34(2), 301-310. doi: 10.21608/ejmm.2025.355041.1448
Sara A. Aboelroos; Amr K. Abotaqia; Hasnaa Azab; Nashwa R. Hassan. "Associations of Single Nucleotide Polymorphism (MMP-9 -1562 C/T rs 3918242) with the Risk of Severity in Adult Multiple Trauma ICU Admitted Patients: A Pilot Study". EKB Journal Management System, 34, 2, 2025, 301-310. doi: 10.21608/ejmm.2025.355041.1448
Aboelroos, S., Abotaqia, A., Azab, H., Hassan, N. (2025). 'Associations of Single Nucleotide Polymorphism (MMP-9 -1562 C/T rs 3918242) with the Risk of Severity in Adult Multiple Trauma ICU Admitted Patients: A Pilot Study', EKB Journal Management System, 34(2), pp. 301-310. doi: 10.21608/ejmm.2025.355041.1448
Aboelroos, S., Abotaqia, A., Azab, H., Hassan, N. Associations of Single Nucleotide Polymorphism (MMP-9 -1562 C/T rs 3918242) with the Risk of Severity in Adult Multiple Trauma ICU Admitted Patients: A Pilot Study. EKB Journal Management System, 2025; 34(2): 301-310. doi: 10.21608/ejmm.2025.355041.1448

Associations of Single Nucleotide Polymorphism (MMP-9 -1562 C/T rs 3918242) with the Risk of Severity in Adult Multiple Trauma ICU Admitted Patients: A Pilot Study

Egyptian Journal of Medical Microbiology
Article 36, Volume 34, Issue 2, April 2025, Page 301-310  XML PDF (382.19 K)
Document Type: New and original researches in the field of Microbiology.
DOI: 10.21608/ejmm.2025.355041.1448
View on SCiNiTO View on SCiNiTO
Authors
Sara A. Aboelroos1; Amr K. Abotaqia2; Hasnaa Azab email orcid 3; Nashwa R. Hassan1
1Clinical and Chemical Pathology Department, Faculty of Medicine, Suez Canal University, Ismailia 41522, Egypt
2Department of Anesthesia and ICU, Faculty of Medicine, Suez Canal University, Ismailia 41522, Egypt
3Microbiology and Immunology Department, Faculty of Medicine, Suez Canal University, Ismailia 41522, Egypt
Abstract
Background: Multiple traumas are injuries involving multiple body parts or organs, with at least one life-threatening injury. Despite advances in trauma care, complications like pneumonia can arise. Genetic variations, such as the MMP9-1562 C/T gene variant, may contribute to these complications. Objectives: This study aimed to investigate the potential association between the MMP-9 -1562 C/T gene variant (rs3918242) and the risk of developing pneumonia in critically injured patients admitted to the Intensive Care Unit (ICU).  Methodology: This study included 120 participants: 40 ICU patients with multiple traumas and pneumonia, 40 with non-complicated multiple traumas, and 40 healthy controls. All participants were assessed using the Injury Severity Scale (ISS) scoring system. MMP9 levels were measured using the Human MMP-9 Quantikine ELISA Kit. The study focused on the MMP-9 -1562 C/T gene variant (rs3918242) to investigate its association with pneumonia susceptibility in severe multiple trauma patients in the ICU. Results: MMP9 levels were higher in patients with complicated multiple trauma and pneumonia, the T allele increased complication risk and WBC, CRP, and MMP9 levels helped differentiate between complicated and non-complicated trauma cases. Conclusion: Our study suggests a link between the MMP9-1562C/T gene variation and pneumonia risk in severely injured ICU patients. The T allele may be a genetic indicator for pneumonia risk in these patients.
Keywords
pneumonia; allele; polymorphism; multiple traumas; MMP9-1562C/T
Statistics
Article View: 97
PDF Download: 32