Possible Impact of Jojoba Nano-Emulsion and/or Vitamin-D on Experimentally- Induced Cutaneous Lesion in Adult Male Albino Rats | ||||
| International Journal of Medical Arts | ||||
| Article 7, Volume 7, Issue 3, March 2025, Page 5460-5467 PDF (1.87 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ijma.2025.347058.2088 | ||||
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| Authors | ||||
Mohammad Abdel-Halim Okasha1; Abdou Mohammed Ahmed El-Sharkawy2; Ahmed Shaban Abdel Monsef3; Mohamed Ramadan Elnady3; Yomna Khaled Mohamed Elgebaly  3
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| 1Department of Medical Physiology, Faculty of Medicine, Al-Azhar University, Cairo, Egypt. | ||||
| 2Department of Anatomy and Embryology, Faculty of Medicine, Al-Azhar University, Cairo, Egypt. | ||||
| 3Department of Medical Physiology, Damietta Faculty of Medicine, Al-Azhar University, Damietta, Egypt. | ||||
| Abstract | ||||
| Background: The body's greatest organ is the epidermis. This is the initial defense against the external environment. Objective: This study aimed to investigate the possible effect of jojoba nano-emulsion with or without vitamin D on experimentally-induced cutaneous lesion in adult male albino rats. Materials and methods: A strain of 28 adult male albino rats was employed. Their body weight ranged between 130-100 g. They were left 2 weeks for accommodation to environment of the laboratory in Al-Azhar Medical Physiology Department. The rats were separated randomly into 4 equal groups as follows: Group I [control group], Group II [vitamin D-treated group], Group III [jojoba nano-emulsion-treated group], Group IV [vitamin D and jojoba nano-emulsion-treated group]. Results: There were significant variances in IL-10 levels among groups, with G2 having non-significant higher levels than G1, G3 and G4 having higher levels than G1, and G3 having higher levels than G2. Vitamin D plus Fucidin did not significantly increase IL-10 compared to Fucidin alone, but jojoba alone or with vitamin D increased IL-10 levels. Vitamin D plus Fucidin led to a mild decrease in TNF-α, but jojoba significantly reduced it. Conclusion: The current study showed that jojoba nano-emulsion either with or without vitamin D were promising on cutaneous lesions healing, but jojoba nano-emulsion with vitamin D showed the most promising results. The combination of jojoba nano-emulsion and vitamin D treatment had a potent anti-inflammatory effect. This was demonstrated by the low levels of pro-inflammatory mediators. The combined treatment also showed superior antioxidant capacity. | ||||
| Keywords | ||||
| Jojoba Nano-emulsion; Vitamin D; Skin Lesion; Albino rats | ||||
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