Evaluation of Accuracy of Chromohysteroscopy as A Diagnostic Strategy for Perimenopausal Bleeding | ||
| The Egyptian Journal of Fertility and Sterility | ||
| Volume 29, Issue 1 - Serial Number 11106352, January 2025, Pages 87-94 PDF (258.12 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/egyfs.2025.409772 | ||
| Authors | ||
| Omar K. Naser* ; Ahmed S. Yassin; Ali A. Bendary | ||
| Department of Obstetric and gynecology, Benha faculty of medicine, Benha University, Egypt | ||
| Abstract | ||
| Objective: To evaluate the role of endometrial dying with methylene blue during diagnostic hysteroscopy to detect new subtle histopathologies missed by the conven-tional hysteroscopy. Methods: One hundred patients were included in the study complaining of perimenopausal bleeding with no diagnosed hysteroscopic endometrial abnormalities nor a general bleeding tendency. Endometrial dying was done by instillation of 5 ml of 1% methylene blue into the en-dometrial cavity after diagnostic hysteroscopy. Accord-ing to the pattern of methylene blue staining, 60 patients showed focal dark staining with a background of light blue stained endometrium forming (group I), the remain-ing 40 patients showed non focal diffuse blue staining forming ( group II ). Group I was further subdivided into group A , B according to the age with group A (40-46 years) and group B (>46 years).. Results: Chromohysteroscopy procedure led to the di-agnosis of 48 more new endometrial histopathologies missed by conventional diagnostic hysteroscopy includ-ing 16 cases of atrophic endometritis, 29 cases of simple endometrial hyperplasia and 3 cases of atypical endome-trial hyperplasia.The overall validity of the chromohys-teroscopy procedure was calculated with a sensitivity of 93.2%, specificity of 87.8%, positive predictive value of 91.6 % and negative predictive value of 90%. Conclusions: Chromohysteroscopy appears to improve the efficacy of hysteroscopy in abnormal uterine bleed-ing and observation of diffuse light blue staining without dark areas strongly suggests a normal endometrium free of endometritis. | ||
| Keywords | ||
| Chromohysteroscopy; Abnormal uterine bleeding; Endometrial biopsy; Methylene blue | ||
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