Assessment expression of Serum Amyloid A and LncRNAAF085935 in patients with Hepatocellular Carcinoma, Hepatitis B and Hepatitis C Virus
El- Hadidy, H., sabry, D., Maher, M., Abd El kader, A., Shousha, H., Anani, H., Diaa, N. (2025). Assessment expression of Serum Amyloid A and LncRNAAF085935 in patients with Hepatocellular Carcinoma, Hepatitis B and Hepatitis C Virus. EKB Journal Management System, 3(1), 1-10. doi: 10.21608/arcmed.2025.342192.1084
Haitham Abbas El- Hadidy; Dina sabry; Moataz Maher; Abeer Eid Abd El kader; Hend Ibrahim Shousha; Haneya Anani; Nihal Diaa. "Assessment expression of Serum Amyloid A and LncRNAAF085935 in patients with Hepatocellular Carcinoma, Hepatitis B and Hepatitis C Virus". EKB Journal Management System, 3, 1, 2025, 1-10. doi: 10.21608/arcmed.2025.342192.1084
El- Hadidy, H., sabry, D., Maher, M., Abd El kader, A., Shousha, H., Anani, H., Diaa, N. (2025). 'Assessment expression of Serum Amyloid A and LncRNAAF085935 in patients with Hepatocellular Carcinoma, Hepatitis B and Hepatitis C Virus', EKB Journal Management System, 3(1), pp. 1-10. doi: 10.21608/arcmed.2025.342192.1084
El- Hadidy, H., sabry, D., Maher, M., Abd El kader, A., Shousha, H., Anani, H., Diaa, N. Assessment expression of Serum Amyloid A and LncRNAAF085935 in patients with Hepatocellular Carcinoma, Hepatitis B and Hepatitis C Virus. EKB Journal Management System, 2025; 3(1): 1-10. doi: 10.21608/arcmed.2025.342192.1084

Assessment expression of Serum Amyloid A and LncRNAAF085935 in patients with Hepatocellular Carcinoma, Hepatitis B and Hepatitis C Virus

ARCADEs of MEDICINE
Volume 3, Issue 1, April 2025, Page 1-10  XML PDF (485.16 K)
Document Type: Review Articles
DOI: 10.21608/arcmed.2025.342192.1084
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Authors
Haitham Abbas El- Hadidy email 1; Dina sabry2; Moataz Maher2; Abeer Eid Abd El kader2; Hend Ibrahim Shousha3; Haneya Anani4; Nihal Diaa5
1General Manager of School of Medicine BUC,Lecturer of Hospital Administration, MMA
2Medical Biochemistry and Molecular Biology department, Faculty of medicine, Cairo University.
3Endemic medicine and Hepatogastroenterology, Faculty of medicine, Cairo University
4Medical microbiology and Immunology department, Faculty of Medicine for Girl, AL- Azhar University
5Clinical and Chemical Pathology Department, Consultant Clinical Pathology, Cairo University Hospitals, Cairo, Egypt
Abstract
Long non coding RNAs (Lnc RNAs) and serum Amyloid A (SAA) have been suggested to have a role in hepatocarcinogenesis. In this work, to investigated the role of lnc RNA AF085935 and SAA as diagnostic biomarkers in sera of HBV, HCV, HCC patients. Subjects and Methods: HBV genotyping was assessed by. Lnc RNAAF085935 quantitative gene expression in whole blood by real time PCR and the SAA expression was measured using ELISA. 149 adult Egyptian subjects were divided into 35 HCC patients on top of HCV and 24 HCC patients on top of HBV, 35patients with HBV, 35 patients with HCV and 20 controls. Results: HBV genotype D was found in all of the samples. In HCC patients, HCV patients, and HBV patients; the levels of LncRNA-AF085935 and SAA were significantly upregulated than in healthy controls. (p value = <0.001). In addition, higher expressions of both LncRNA-AF085935 and SAA (p value = <0.001) were observed in HCC/HBV and HCC/HCV patients than in HCV or HBV patients. Conclusion: Lnc RNA-AF085935 and SAA were observed with an aberrant level in sera of HCC, HCV and HBV patients. Lnc RNA-AF085935 and/or SAA can be considered to be used as potential biomarkers in HCC.
Keywords
Hepatitis B; Hepatitis C Virus; Hepatocellular Carcinoma; LncRNAAF085935; Serum Amyloid
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