CYANOACETANILIDES IN HETEROCYCLIC SYNTHESIS (PART IV): A CONVENIENT ONE-STEP SYNTHESIS OF 2-IMINO CHROMENE-3- CARBOXAMIDE, CHROMENONE, BENZOCHROMENE, CHROMENOCOUMARIN AND CHROMENOPYRIDINE DERIVATIVES FOR ANTIMICROBIAL EVALUATION
M., E., G., E., M., A., A., S., A., M., A., A. (2006). CYANOACETANILIDES IN HETEROCYCLIC SYNTHESIS (PART IV): A CONVENIENT ONE-STEP SYNTHESIS OF 2-IMINO CHROMENE-3- CARBOXAMIDE, CHROMENONE, BENZOCHROMENE, CHROMENOCOUMARIN AND CHROMENOPYRIDINE DERIVATIVES FOR ANTIMICROBIAL EVALUATION. EKB Journal Management System, 3(3rd International Conference On Chemical & Environmental Engineering), 233-242. doi: 10.21608/iccee.2006.40998
El-Sharief A. M.; El-Sehemi A. G.; Aly M. M.; Salem M. A.; Mohamed Y. A.; Ammar Y. A.. "CYANOACETANILIDES IN HETEROCYCLIC SYNTHESIS (PART IV): A CONVENIENT ONE-STEP SYNTHESIS OF 2-IMINO CHROMENE-3- CARBOXAMIDE, CHROMENONE, BENZOCHROMENE, CHROMENOCOUMARIN AND CHROMENOPYRIDINE DERIVATIVES FOR ANTIMICROBIAL EVALUATION". EKB Journal Management System, 3, 3rd International Conference On Chemical & Environmental Engineering, 2006, 233-242. doi: 10.21608/iccee.2006.40998
M., E., G., E., M., A., A., S., A., M., A., A. (2006). 'CYANOACETANILIDES IN HETEROCYCLIC SYNTHESIS (PART IV): A CONVENIENT ONE-STEP SYNTHESIS OF 2-IMINO CHROMENE-3- CARBOXAMIDE, CHROMENONE, BENZOCHROMENE, CHROMENOCOUMARIN AND CHROMENOPYRIDINE DERIVATIVES FOR ANTIMICROBIAL EVALUATION', EKB Journal Management System, 3(3rd International Conference On Chemical & Environmental Engineering), pp. 233-242. doi: 10.21608/iccee.2006.40998
M., E., G., E., M., A., A., S., A., M., A., A. CYANOACETANILIDES IN HETEROCYCLIC SYNTHESIS (PART IV): A CONVENIENT ONE-STEP SYNTHESIS OF 2-IMINO CHROMENE-3- CARBOXAMIDE, CHROMENONE, BENZOCHROMENE, CHROMENOCOUMARIN AND CHROMENOPYRIDINE DERIVATIVES FOR ANTIMICROBIAL EVALUATION. EKB Journal Management System, 2006; 3(3rd International Conference On Chemical & Environmental Engineering): 233-242. doi: 10.21608/iccee.2006.40998

CYANOACETANILIDES IN HETEROCYCLIC SYNTHESIS (PART IV): A CONVENIENT ONE-STEP SYNTHESIS OF 2-IMINO CHROMENE-3- CARBOXAMIDE, CHROMENONE, BENZOCHROMENE, CHROMENOCOUMARIN AND CHROMENOPYRIDINE DERIVATIVES FOR ANTIMICROBIAL EVALUATION

The International Conference on Chemical and Environmental Engineering
Article 3, Volume 3, 3rd International Conference On Chemical & Environmental Engineering, May 2006, Pages 233-242    PDF (251.77 K)
Document Type: Original Article
DOI: 10.21608/iccee.2006.40998
Authors
El-Sharief A. M.1; El-Sehemi A. G.2; Aly M. M.1; Salem M. A.1; Mohamed Y. A.1; Ammar Y. A.1
1Faculty of Science, Al-Azhar University.
2Chemistry Department, Teacher s Colleges, Abha Saudia.
Abstract
ABSTRACT
Cyanoacetanilides (1a,b) were reacted with o-hydroxyaldehydes under different
conditions. Thus, cyclocondensation of 1a,b with salicylaldehyde, 2-hydroxy-1-
naphth-aldehyde and 7-hydroxy-5-methoxycoumarin-6-carboxaldehyde in ethanolic
amm. acetate afforded the corresponding 2-iminochromene derivatives 3,7 and 9
respectively. On the other hand, repeating the same reaction in presence of
Ac2O/AcONa, the corresponding chromen-2-one derivatives 4, 8 and 10 were
obtained. Compounds 4,8 and 10 were also synthesized through the hydrolysis of 2-
imino derivatives using EtOH/HCl. A number of chromeno[3,4-c]-pyridine derivatives
11,13,14 and 16 were prepared from the reaction of 2-iminochromenes with
malononitrile, ethyl cyanoacetate, and cyanoacetanilide. Some of these compounds
were screened in vitro for their antimicrobial activities.
Keywords
Chromenone; Benzochromene; Chromenocoumarin; Chromeno-pyridine; antimicrobial activity
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