ASSOCIATION OF INTERLEUKIN 1 RECEPTOR TYPE 1 POLYMORPHISM RS956730 WITH VITILIGO SUSCEPTIBILITY IN ASSIUT UNIVERSITY HOSPITALS, ASSIUT, EGYPT
Hussien, A., Sayed Ahmed Siefeldien, S., Hofny, E., Abdel-Rahim, M., Rashwan, R. (2025). ASSOCIATION OF INTERLEUKIN 1 RECEPTOR TYPE 1 POLYMORPHISM RS956730 WITH VITILIGO SUSCEPTIBILITY IN ASSIUT UNIVERSITY HOSPITALS, ASSIUT, EGYPT. EKB Journal Management System, 48(1), 597-606. doi: 10.21608/bfsa.2025.339397.2357
Abdelrahman Elsayed Ahmed Hussien; Salwa Sayed Ahmed Siefeldien; Eman Riad Mohamed Hofny; Mona Hussien Mohamed Abdel-Rahim; Ragaa Sedeik Rashwan. "ASSOCIATION OF INTERLEUKIN 1 RECEPTOR TYPE 1 POLYMORPHISM RS956730 WITH VITILIGO SUSCEPTIBILITY IN ASSIUT UNIVERSITY HOSPITALS, ASSIUT, EGYPT". EKB Journal Management System, 48, 1, 2025, 597-606. doi: 10.21608/bfsa.2025.339397.2357
Hussien, A., Sayed Ahmed Siefeldien, S., Hofny, E., Abdel-Rahim, M., Rashwan, R. (2025). 'ASSOCIATION OF INTERLEUKIN 1 RECEPTOR TYPE 1 POLYMORPHISM RS956730 WITH VITILIGO SUSCEPTIBILITY IN ASSIUT UNIVERSITY HOSPITALS, ASSIUT, EGYPT', EKB Journal Management System, 48(1), pp. 597-606. doi: 10.21608/bfsa.2025.339397.2357
Hussien, A., Sayed Ahmed Siefeldien, S., Hofny, E., Abdel-Rahim, M., Rashwan, R. ASSOCIATION OF INTERLEUKIN 1 RECEPTOR TYPE 1 POLYMORPHISM RS956730 WITH VITILIGO SUSCEPTIBILITY IN ASSIUT UNIVERSITY HOSPITALS, ASSIUT, EGYPT. EKB Journal Management System, 2025; 48(1): 597-606. doi: 10.21608/bfsa.2025.339397.2357

ASSOCIATION OF INTERLEUKIN 1 RECEPTOR TYPE 1 POLYMORPHISM RS956730 WITH VITILIGO SUSCEPTIBILITY IN ASSIUT UNIVERSITY HOSPITALS, ASSIUT, EGYPT

Bulletin of Pharmaceutical Sciences Assiut University
Volume 48, Issue 1, June 2025, Page 597-606  XML PDF (867.91 K)
Document Type: Original Article
DOI: 10.21608/bfsa.2025.339397.2357
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Authors
Abdelrahman Elsayed Ahmed Hussien1; Salwa Sayed Ahmed Siefeldien2; Eman Riad Mohamed Hofny3; Mona Hussien Mohamed Abdel-Rahim2; Ragaa Sedeik Rashwan email 2
1Department of Microbiology and Immunology, Faculty of Pharmacy, Assiut university, Assiut, Egypt
2Medical Microbiology and Immunology Department, Faculty of Medicine, Assiut university, Assiut, Egypt
3Dermatology Department, Faculty of Medicine, Assiut university, Assiut, Egypt
Abstract
Background and aims: Vitiligo, an autoimmune skin condition, largely resulted from genetic factor. Vitiligo is distinguished by white regions of skin that have lost the capacity to create pigment from melanocytes. IL-1 receptor (IL1R1) performs a vital function in the immunological and inflammatory responses triggered by various cytokines. It has been correlated with other disorders of the immunological system such as systemic lupus erythematous, inflammatory spondylitis and rheumatoid arthritis. This study aimed to evaluate the correlation of IL1R1 gene polymorphisms (rs956730) and vitiligo pathogenesis. Patients and methods: It was a case-control investigation which included 100 patients suffering from vitiligo, in addition to 100 apparently healthy individuals, recruited to the Dermatology Department, Assiut University, Egypt. The IL1R1 single nucleotide polymorphism (SNP) rs956730 was genotyped by RT-PCR. Results: The allele frequency in the SNP rs956730 shows a significant difference between vitiligo patients and healthy subjects. AA genotype was 65.0% among cases versus 25.0% among controls. So, carriers of AA genotype were at risk condition for vitiligo (OR = 8.03, p-value 0.001). Conclusion: The present study suggested that A allele of IL1R1 rs956730 is risk factor associated with the development of vitiligo.
Keywords
Vitiligo; Interleukin 1 receptor type-1; SNP; Polymorphism; Real Time PCR
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