INNOVATION OF MICROEMULSION SYSTEMS REVERSE MICELLE MENIRAN EXTRACT (Phyllanthus niruri) AS A CERVICAL ANTICANCER IN THE DEVELOPMENT OF HERBAL MEDICINE
Faizah, F., Putri, L., Azmi, M., Putri, S., Silalahi, Z., Widyowati, R. (2025). INNOVATION OF MICROEMULSION SYSTEMS REVERSE MICELLE MENIRAN EXTRACT (Phyllanthus niruri) AS A CERVICAL ANTICANCER IN THE DEVELOPMENT OF HERBAL MEDICINE. EKB Journal Management System, 48(1), 49-57. doi: 10.21608/bfsa.2025.324106.2299
Fany Zumrotul Faizah; Leivina Ariani Sugiharto Putri; M. Rofiqi Azmi; Shavira Priyantika Putri; Zavirah Silalahi; Rr. Retno Widyowati. "INNOVATION OF MICROEMULSION SYSTEMS REVERSE MICELLE MENIRAN EXTRACT (Phyllanthus niruri) AS A CERVICAL ANTICANCER IN THE DEVELOPMENT OF HERBAL MEDICINE". EKB Journal Management System, 48, 1, 2025, 49-57. doi: 10.21608/bfsa.2025.324106.2299
Faizah, F., Putri, L., Azmi, M., Putri, S., Silalahi, Z., Widyowati, R. (2025). 'INNOVATION OF MICROEMULSION SYSTEMS REVERSE MICELLE MENIRAN EXTRACT (Phyllanthus niruri) AS A CERVICAL ANTICANCER IN THE DEVELOPMENT OF HERBAL MEDICINE', EKB Journal Management System, 48(1), pp. 49-57. doi: 10.21608/bfsa.2025.324106.2299
Faizah, F., Putri, L., Azmi, M., Putri, S., Silalahi, Z., Widyowati, R. INNOVATION OF MICROEMULSION SYSTEMS REVERSE MICELLE MENIRAN EXTRACT (Phyllanthus niruri) AS A CERVICAL ANTICANCER IN THE DEVELOPMENT OF HERBAL MEDICINE. EKB Journal Management System, 2025; 48(1): 49-57. doi: 10.21608/bfsa.2025.324106.2299

INNOVATION OF MICROEMULSION SYSTEMS REVERSE MICELLE MENIRAN EXTRACT (Phyllanthus niruri) AS A CERVICAL ANTICANCER IN THE DEVELOPMENT OF HERBAL MEDICINE

Bulletin of Pharmaceutical Sciences Assiut University
Volume 48, Issue 1, June 2025, Page 49-57  XML PDF (683.23 K)
Document Type: Original Article
DOI: 10.21608/bfsa.2025.324106.2299
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Authors
Fany Zumrotul Faizah email orcid 1; Leivina Ariani Sugiharto Putriorcid 1; M. Rofiqi Azmiorcid 1; Shavira Priyantika Putriorcid 1; Zavirah Silalahiorcid 1; Rr. Retno Widyowatiorcid 2
1Undergraduate Student of Apothecary Education Program, Faculty of Pharmacy, Airlangga University, Surabaya, Indonesia
2Department of Pharmaceutical Sciences, Faculty of Pharmacy, Airlangga University, Surabaya, Indonesia
Abstract
Prolonged chemotherapy increases side effects that are treated with herbs, such as meniran. Cancer cells have high lipophilicity and Log P corilagin meniran has low bioavailability. The encapsulation of the active ingredient in the reverse micelle system can increase the value of the P log and work selectively. This research aims to determine the effectiveness of the Microemulsion System Reverse Micelle Meniran (MSRMM), a cervical anticancer, in developing herbal medicine. The formulations determine the span of 80 levels that form optimally based on their characterization and effectiveness. The methods included MSRMM making, characterization, and in vitro tests. The results showed that MSRMM F2 (0.50 % span 80) meets optimal requirements, especially droplet size parameters of 2226.4 nm, PDI of 0.2129, and zeta potential of -26.4 mV. MSRMM F2 cervical anticancer IC50 was 171.190 µg/mL and P = 0.047 (P<0.05) compared to meniran extract. In conclusion, MSRMM F2 is the selected formula and has potential as a cervical anticancer herbal drug.
Keywords
cervical anticancer; meniran; microemulsion; reverse micelle
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