Evaluation the diagnostic and prognostic value of PCA3, PSA, IL-6 and TNF-α in prostate cancer and benign prostate hyperplasia | ||||
| Journal of Bioscience and Applied Research | ||||
| Volume 11, Issue 1, March 2025, Page 101-109 PDF (1.19 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/jbaar.2025.333344.1101 | ||||
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| Authors | ||||
Athraa Al-Khater  1; Huda Al-awani2; Waleed Aljafaal3
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| 1Department of microbiology, College of Medicine, University of Anbar, Anbar, Ramadi, Iraq | ||||
| 2Department of Microbiology, College of Medicine University of Anbar, Anbar, Ramadi, Iraq | ||||
| 3Department of Urology, College of Medicine, University of Anbar, Anbar, Ramadi, Iraq | ||||
| Abstract | ||||
| Background: Prostate cancer detection relies on blood Prostate Specific Antigen (PSA) levels, prostate cancer antigen (PCA3) is potentially more accurate in this topic, and some cytokines may have a role in disease progression. Aim: To evaluate the role of PCA3 in early detection of prostate cancer and also evaluate the correlation between IL-6 and TNF-α with prostate cancer progression. Materials and methods: The study involved 90 participants, PSA, PCA3, IL-6, and TNF-α were analyzed using ELISA techniques using a kit from Sun Long Biotech Company. Results: The PSA level in prostate cancer patients (Pc) was (5.36 ± 1.97), in prostate benign hyperplasia (PBH) was (3.62 ± 1.25) and in healthy individuals (2.83 ± 0.965). The mean PCA3 level was (36.02 ± 10.55), (27.83 ± 6.05), and (18.55 ± 5.30) in the PC, PBH, and healthy groups, respectively. The mean IL-6 level in PC patients was (60.87 ± 18.83), while in the BPH patients was (45.56 ± 16.28) and in the healthy group (24.32 ± 7.80), the level of TNF-α in PC was (246.36 ± 106.76), in BPH was (162.17 ± 83.31), and in the healthy group was (78.30 ± 39.85). For all biomarkers, there are significant differences between the three groups as indicated by the p-value (0.0001). PCA3 and TNF-α show high specificity (91% and 93%, respectively) in patients with PC. Conclusion: The study reveals that PCA3 is more effective in detecting prostate cancer than PSA and IL-6 and TNF-α may be linked to prostate cancer progression. | ||||
| Keywords | ||||
| prostate cancer; benign prostate hyperplasia; prostate specific antigen; prostate cancer antigen; IL- 6 | ||||
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