VALIDATION OF NOVEL SEPSIS SUB-PHENOTYPES USING TRAJECTORIES OF VITAL SIGNS AT ALEXANDRIA PEDIATRIC INTENSIVE CARE UNIT | ||
| ALEXMED ePosters | ||
| Article 1, Volume 7, Issue 1, January 2025, Pages 29-30 | ||
| Document Type: Preliminary preprint short reports of original research | ||
| DOI: 10.21608/alexpo.2025.358294.2084 | ||
| Authors | ||
| magdy abdelfatah Ramadan1; Manal abdelmalak2; Ashley Hassan Alhinai* 2 | ||
| 1Department of Pediatric, Faculty of Medicine, Alexandria University, Egypt | ||
| 2Department of Pediatrics, Faculty of Medicine, Alexandria University | ||
| Abstract | ||
| Introduction Sepsis is a major global health threat, particularly for children, contributing to significant morbidity and mortality. The WHO recognizes it as a leading cause of death in pediatric intensive care units (PICUs), with mortality rates exceeding 50% in developing countries. Sepsis is caused by an abnormal immune response to infection, leading to life-threatening organ dysfunction. Early diagnosis and treatment are essential for improving outcomes. Recent studies suggest that identifying sub-phenotypes could enable more personalized management strategies. These sub-phenotypes may display distinct baseline characteristics, laboratory abnormalities, and patterns of organ dysfunction. However, data on sepsis remains limited, and understanding of its sub-phenotypes—distinct classifications based on responses to treatment—remains incomplete and are areas of ongoing research. Identifying these sub-phenotypes could improve diagnosis, intervention timing, and monitoring. Aim of the work This study aims to validate novel sepsis sub-phenotyping based on vital signs trajectories in pediatric severe sepsis and correlate these sub-phenotypes with clinical outcomes, complications, PICU stay length, and mechanical ventilation need. | ||
| Keywords | ||
| NOVEL; SEPSIS; SUB-PHENOTYPES | ||
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