The potential association between diabetes mellitus type 2 and depression. Role of L-carnitine. An experimental study on adult albino rats | ||||
| Benha Medical Journal | ||||
| Articles in Press, Accepted Manuscript, Available Online from 06 February 2025 PDF (1.43 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/bmfj.2025.344849.2292 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Abeer Attia Abdel-hameed1; Ahmed Selim Mohamed1; Omaima Mohammed Abdullah2; Mahitab Essam Ahmed Gahgah  3; Abeer Ali Eldeeb4
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| 1Department of Clinical Pharmacology, Faculty of Medicine-Benha University | ||||
| 2Department of Clinical Pharmacology, Faculty of Medicine-Benha University | ||||
| 3M.B.B.CH Clinical Pharmacology, Faculty of Medicine- Suez University | ||||
| 4Department of Pharmacology, Faculty of Medicine-Benha University | ||||
| Abstract | ||||
| Background: Comorbid diabetes and depression are significant public health burdens as the consequences of both diseases are worsened by each other. Aim of the study: This work was designed to explore the potential effect of L-carnitine (LC) alone and in combination with paroxetine and dapagliflozin in depression-like behavior diabetic rats Material and Methods: Rats were randomized into 8 groups (6 rats for each): control group, diabetic-untreated group, Pre-diabetic LC treated group received prophylactic LC (300mg/kg/day, orally) at start of 7th week, LC-treated diabetic group: received LC (300mg/kg/day, orally) for 6 weeks after induction of diabetes, paroxetine-treated diabetic group: received paroxetine (20 mg/kg/day orally) for 6 weeks after induction of diabetes., dapagliflozin-treated diabetic group: received dapagliflozin (1.5 mg/kg/day orally) for 6 weeks after induction of diabetes., LC + dapagliflozin-treated diabetic group: received LC and dapagliflozin for 6 weeks after induction of diabetes., and LC + paroxetine-treated diabetic group: received LC and paroxetine for 6 weeks after induction of diabetes. Results: Treated groups showed significant improvement in all parameters: body weight, fasting blood glucose, fasting insulin level, HOMA-IR, pro-inflammatory cytokines (INF-γ and IL1-β), malondialdehyde (MDA), super-oxide dismutase (SOD), cortisol level, serotonin, and dopamine, assess of depressive behavior by; open field test, tail suspension test, and improvement in the histopathological changes of the brain. Conclusions: L-carnitine is a promising agent in the management of diabetes mellitus type-2 associated with depression either singly or in combination with dapagliflozin and paroxetine | ||||
| Keywords | ||||
| Diabetes Mellitus Type 2; Depression; L-Carnitine; paroxetine; dapagliflozin | ||||
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