Mystery Behind COVID-19 and Autoimmune Diseases | ||
| Egyptian Journal of Medical Microbiology | ||
| Article 39, Volume 34, Issue 2, April 2025, Pages 325-334 PDF (1.02 M) | ||
| Document Type: Review articles | ||
| DOI: 10.21608/ejmm.2025.354622.1447 | ||
| Authors | ||
| Samaa A. Taha* 1; Mona M, Ali2; Enaam M. Junainah3; Nuha N. Filfilan4; Usama M. Marzouk5 | ||
| 1Microbiology Department- Faculty of Medicine- Suez- Canal University; Department of Microbiology and Immunology- College of Medicine- Taif University, Taif 21974, Saudi Arabia | ||
| 2Department of Forensic Medicine and Clinical Toxicology, College of Medicine, Taif University, Taif 21974, Saudi Arabia | ||
| 3Department of Pathology, College of Medicine, Taif University, Taif 21974, Saudi Arabia | ||
| 4Department of Family and Community Medicine, College of Medicine, Taif University, Taif 21974, Saudi Arabia | ||
| 5Department of Internal medicine, Faculty of Medicine, Ain- Shams University | ||
| Abstract | ||
| Background: Viruses cause autoimmunity using several mechanisms such as molecular mimicry, bystander activation of T cells, transient immunosuppression, and inflammation. Objective: To understand the link between Coronavirus disease 2019 (COVID-19), autoimmunity and hyperstimulation of the immune system which is still an unknown mystery. Methodology: We reviewed many research articles about the mechanisms used by SARS-CoV-2 to induce autoimmunity. We tried to explain in detail these mechanisms including molecular mimicry, the role of innate immunity, the role of adaptive immunity and autoantibodies detected in patients with COVID-19. Also, giving insights into similarities in immunopathogenesis of COVID-19 and autoimmune diseases, listing autoimmune diseases associated with COVID-19, clarifying the impact of covid-19 on pre-existing autoimmune diseases and finally presenting some therapeutic strategies & future prospectives for this disease. Conclusion: Autoimmune diseases are serious complications induced by SARS-CoV-2, which need more understanding by researchers to help develop appropriate treatment. | ||
| Keywords | ||
| COVID-19; Autoimmunity; Innate immunity; Adaptive immunity and Autoantibodies | ||
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