Mystery Behind COVID-19 and Autoimmune Diseases | ||||
Egyptian Journal of Medical Microbiology | ||||
Article 39, Volume 34, Issue 2, April 2025, Page 325-334 PDF (1.02 MB) | ||||
Document Type: Review articles | ||||
DOI: 10.21608/ejmm.2025.354622.1447 | ||||
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Authors | ||||
Samaa A. Taha ![]() | ||||
1Microbiology Department- Faculty of Medicine- Suez- Canal University; Department of Microbiology and Immunology- College of Medicine- Taif University, Taif 21974, Saudi Arabia | ||||
2Department of Forensic Medicine and Clinical Toxicology, College of Medicine, Taif University, Taif 21974, Saudi Arabia | ||||
3Department of Pathology, College of Medicine, Taif University, Taif 21974, Saudi Arabia | ||||
4Department of Family and Community Medicine, College of Medicine, Taif University, Taif 21974, Saudi Arabia | ||||
5Department of Internal medicine, Faculty of Medicine, Ain- Shams University | ||||
Abstract | ||||
Background: Viruses cause autoimmunity using several mechanisms such as molecular mimicry, bystander activation of T cells, transient immunosuppression, and inflammation. Objective: To understand the link between Coronavirus disease 2019 (COVID-19), autoimmunity and hyperstimulation of the immune system which is still an unknown mystery. Methodology: We reviewed many research articles about the mechanisms used by SARS-CoV-2 to induce autoimmunity. We tried to explain in detail these mechanisms including molecular mimicry, the role of innate immunity, the role of adaptive immunity and autoantibodies detected in patients with COVID-19. Also, giving insights into similarities in immunopathogenesis of COVID-19 and autoimmune diseases, listing autoimmune diseases associated with COVID-19, clarifying the impact of covid-19 on pre-existing autoimmune diseases and finally presenting some therapeutic strategies & future prospectives for this disease. Conclusion: Autoimmune diseases are serious complications induced by SARS-CoV-2, which need more understanding by researchers to help develop appropriate treatment. | ||||
Keywords | ||||
COVID-19; Autoimmunity; Innate immunity; Adaptive immunity and Autoantibodies | ||||
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