Hypo-Fractionation Radiotherapy in Breast Cancer Patients: Review Article | ||||
| The Egyptian Journal of Hospital Medicine | ||||
| Article 102, Volume 98, Issue 1, January 2025, Page 706-712 PDF (609.83 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejhm.2025.410682 | ||||
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| Abstract | ||||
| In breast carcinoma management, radiation therapy (RT) is a necessary management. The typical therapeutic regimen for RT to the breast involves administering 25 fractions of 2.0 Gy per day over a five-week period. Breast cancer is more suitable for greater fraction sizes than squamous carcinomas, according to datasupporting the use of fewer fractions of more than 2 Gy per day (hypo-fractionation). Consequently, it may exhibit similarly high fractionation sensitivity to the dose-limiting normal tissues, such as muscle, subcutaneous tissues, skin, and ribs. This article examins the literature that supports the hypo-fractionated radiation efficacy in breast cancer treatment, explore the radiobiological rationale that is unique to carcinomas of breast, and present a case for the regimen implementation of shorter, hypo-fractionated RT sessions when radiation administered on breast. | ||||
| Keywords | ||||
| Hypo-fractionation; breast cancer; radiotherapy; conventional fractionation; radiobiology | ||||
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