Molecular and Immunological assessment of anticancer activity of 1,2,4-triazolo[4,3-b] [1,2,4] triazole derivative in combination with Artemisia Judaica Extract in Murine Lung cancer model.
Zidane, A., Mahmoud, E., Hamisa, A., Mokhamer, E. (2025). Molecular and Immunological assessment of anticancer activity of 1,2,4-triazolo[4,3-b] [1,2,4] triazole derivative in combination with Artemisia Judaica Extract in Murine Lung cancer model.. EKB Journal Management System, 7(1), 60-84. doi: 10.21608/jmals.2025.410693
Abdel Aziz Zidane; Elsayed Abdel Rehem Mahmoud; Amira Hamisa; El-Hassan Mokhamer. "Molecular and Immunological assessment of anticancer activity of 1,2,4-triazolo[4,3-b] [1,2,4] triazole derivative in combination with Artemisia Judaica Extract in Murine Lung cancer model.". EKB Journal Management System, 7, 1, 2025, 60-84. doi: 10.21608/jmals.2025.410693
Zidane, A., Mahmoud, E., Hamisa, A., Mokhamer, E. (2025). 'Molecular and Immunological assessment of anticancer activity of 1,2,4-triazolo[4,3-b] [1,2,4] triazole derivative in combination with Artemisia Judaica Extract in Murine Lung cancer model.', EKB Journal Management System, 7(1), pp. 60-84. doi: 10.21608/jmals.2025.410693
Zidane, A., Mahmoud, E., Hamisa, A., Mokhamer, E. Molecular and Immunological assessment of anticancer activity of 1,2,4-triazolo[4,3-b] [1,2,4] triazole derivative in combination with Artemisia Judaica Extract in Murine Lung cancer model.. EKB Journal Management System, 2025; 7(1): 60-84. doi: 10.21608/jmals.2025.410693

Molecular and Immunological assessment of anticancer activity of 1,2,4-triazolo[4,3-b] [1,2,4] triazole derivative in combination with Artemisia Judaica Extract in Murine Lung cancer model.

Journal of Medical and Life Science
Volume 7, Issue 1, March 2025, Pages 60-84    PDF (2.96 M)
Document Type: Original Article
DOI: 10.21608/jmals.2025.410693
Authors
Abdel Aziz Zidane1; Elsayed Abdel Rehem Mahmoud2; Amira Hamisa1; El-Hassan Mokhamer* 1
1Zoology Department, Faculty of Science, Damanhour University
2Chemistry Department, Faculty of Science, Damanhour University
Abstract
Lung cancer remains a leading cause of cancer-related mortality worldwide, emphasizing the urgent need for innovative therapeutic strategies. This study evaluates the anti-cancer impact of Artemisia Judaica (AJ) and 1,2,4-triazole derivatives (TRI), both individually and in combination, against lung cancer. Immunohistochemical (IHC) analysis revealed significant modulation in the expression of Caspase-3, Caspase-7, and tumor necrosis factor-alpha (TNF-α), indicating enhanced apoptosis and immune responses. Molecular investigations further demonstrated the compounds’ regulatory effects on key oncogenic pathways, specifically EGFR and BRAF. Notably, the combined therapy displayed a synergistic effect, underscoring its potential as a novel therapeutic approach for lung cancer. These findings highlight AJ and 1,2,4-triazole derivatives as promising candidates for further clinical evaluation and development in lung cancer management.
Keywords
lung Cancer; Artemisia Judaica; 1; 2; 4-triazole derivatives; caspase-3; caspase-7; TNF-α
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