Evaluation of Serum L-carnitine in Late Onset Neonatal Sepsis | ||
| International Journal of Medical Arts | ||
| Article 9, Volume 7, Issue 3, March 2025, Pages 5474-5479 PDF (1.47 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ijma.2025.351335.2098 | ||
| Authors | ||
| Doaa Abdelazeim Youssef Elabd* 1; Hussein Metwally Abdelmaksoud2; Anas Mohamed Elshreif2; Hesham Samir Abd Elsamie3 | ||
| 1Department of Pediatrics, Kafr Saad Specialized Hospital, Ministry of Health, Damietta, Egypt | ||
| 2Department of Pediatrics, Damietta Faculty of Medicine, Al-Azhar University, Damietta, Egypt. | ||
| 3Department of Clinical Pathology, Damietta Faculty of Medicine, Al-Azhar University, Damietta, Egypt. | ||
| Abstract | ||
| Background: Neonatal sepsis is defined as a systemic inflammatory response elicited by blood-stream infection. It is associated with high morbidity and mortality, especially during the first 28 days of life [neonatal period], particularly in resource limited settings. Aim of work: The aim of the work was to evaluate serum level of carnitine in neonate with sepsis. In addition, to study the relation between L-carnitine concentration with birth data and the presence of neonatal sepsis. Subjects and methods: This was a case control study, which was conducted at Al-Azhar University Hospital [New Damietta; Egypt]. It included 60 neonates, 30 with neonatal sepsis [the sepsis group], and 30 without sepsis [control group]. All were carefully evaluated by neonatal and maternal history taking, clinical examination and laboratory workup. Serum-L-carnitine was measured and values were compared between groups and correlated with other variables. The predictive power of L-carnitine in diagnosis sepsis and prediction of its associated mortality was calculated. Results: L-carnitine levels were significantly reduced in sepsis than healthy controls [3.6±0.99 vs. 15.3±2.1 mg/l]. Serum carnitine less than 4.69 had a significant value for sepsis prediction with sensitivity of 90%, specificity of 70% and area under curve of 0.83. In addition, serum carnitine less than 2.97 had a significant value for prediction of mortality [sensitivity of 80%, specificity of 89% and area under curve equal 0.86]. sepsis associated mortality was 16.7%. Finally, there was moderate negative significant correlation between serum carnitine with C-reactive protein [r=-0.68] and total leucocyte count [r=-0.44]; while, there was mild positive significant correlation between serum carnitine and birth weight [r=-0.26] and hemoglobin [r=0.27]. Conclusion: L-carnitine is significantly reduced in neonatal sepsis and it can be used as predictor for neonatal sepsis and sepsis-related mortality. | ||
| Keywords | ||
| Birth weight; L-carnitine; Neonates; Prediction; Sepsis | ||
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