Molecular evaluation of the anticancer potential of 1,3,4-oxadiazole-2-thiones derivative and its synergetic action with Nigella sativa seed extract (Thymoquinone) in experimentally induced Murine Lung Cancer Cell Line Model. | ||
| Journal of Medical and Life Science | ||
| Volume 6, Issue 4, December 2024, Pages 566-587 PDF (1.91 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/jmals.2024.410841 | ||
| Authors | ||
| Abdel Aziz Zidane1; Elsayed Abdel Rehem Mahmoud2; Mahmoud Tarek1; El-Hassan Mokhamer* 1 | ||
| 1Zoology Department, Faculty of Science, Damanhour University, Egypt | ||
| 2Chemistry Department, Faculty of Science, Damanhour University, Egypt | ||
| Abstract | ||
| Lung cancer persistently poses as a primary factor in cancer-linked deaths globally, necessitating novel treatment strategies. This investigation appraises the anti-tumor potential of Thymoquinone (TQ) and 1,3,4-oxadiazole derivatives independently and jointly against lung malignancy. immunohistochemical (IHC) analysis exhibited meaningful alteration of Bcl-2, CD4, and CD8 manifestation, signifying heightened apoptosis and immune response. Molecular studies demonstrated the compounds' ability to adjust key genes involved in cancer development, specifically Caspase-1 and mTOR pathways. The combined therapy exhibited synergistic impacts, suggesting a promising approach for lung cancer management. These conclusions highlight the potential of TQ and 1,3,4-oxadiazole as effective therapeutic agents, warranting further clinical exploration and research. | ||
| Keywords | ||
| Lung cancer; Thymoquinone; 1; 3; 4 oxadiazole; Bcl2; CD4; CD8; mTOR; Caspase1 | ||
|
Statistics Article View: 191 PDF Download: 117 |
||
