Molecular evaluation of the anticancer potential of 1,3,4-oxadiazole-2-thiones derivative and its synergetic action with Nigella sativa seed extract (Thymoquinone) in experimentally induced Murine Lung Cancer Cell Line Model.

Zidane, Abdel Aziz; Mahmoud, Elsayed Abdel Rehem; Tarek, Mahmoud; Mokhamer, El-Hassan

doi:10.21608/jmals.2024.410841

	Molecular evaluation of the anticancer potential of 1,3,4-oxadiazole-2-thiones derivative and its synergetic action with Nigella sativa seed extract (Thymoquinone) in experimentally induced Murine Lung Cancer Cell Line Model.
Journal of Medical and Life Science
Volume 6, Issue 4, December 2024, Page 566-587 PDF (1.91 MB)
Document Type: Original Article
DOI: 10.21608/jmals.2024.410841
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Authors
Abdel Aziz Zidane¹; Elsayed Abdel Rehem Mahmoud²; Mahmoud Tarek¹; El-Hassan Mokhamer^* ¹
¹Zoology Department, Faculty of Science, Damanhour University, Egypt
²Chemistry Department, Faculty of Science, Damanhour University, Egypt
Abstract
Lung cancer persistently poses as a primary factor in cancer-linked deaths globally, necessitating novel treatment strategies. This investigation appraises the anti-tumor potential of Thymoquinone (TQ) and 1,3,4-oxadiazole derivatives independently and jointly against lung malignancy. immunohistochemical (IHC) analysis exhibited meaningful alteration of Bcl-2, CD4, and CD8 manifestation, signifying heightened apoptosis and immune response. Molecular studies demonstrated the compounds' ability to adjust key genes involved in cancer development, specifically Caspase-1 and mTOR pathways. The combined therapy exhibited synergistic impacts, suggesting a promising approach for lung cancer management. These conclusions highlight the potential of TQ and 1,3,4-oxadiazole as effective therapeutic agents, warranting further clinical exploration and research.
Keywords
Lung cancer; Thymoquinone; 1; 3; 4 oxadiazole; Bcl2; CD4; CD8; mTOR; Caspase1


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