Molecular evaluation of the anticancer potential of 1,3,4-oxadiazole-2-thiones derivative and its synergetic action with Nigella sativa seed extract (Thymoquinone) in experimentally induced Murine Lung Cancer Cell Line Model.
Zidane, A., Mahmoud, E., Tarek, M., Mokhamer, E. (2024). Molecular evaluation of the anticancer potential of 1,3,4-oxadiazole-2-thiones derivative and its synergetic action with Nigella sativa seed extract (Thymoquinone) in experimentally induced Murine Lung Cancer Cell Line Model.. EKB Journal Management System, 6(4), 566-587. doi: 10.21608/jmals.2024.410841
Abdel Aziz Zidane; Elsayed Abdel Rehem Mahmoud; Mahmoud Tarek; El-Hassan Mokhamer. "Molecular evaluation of the anticancer potential of 1,3,4-oxadiazole-2-thiones derivative and its synergetic action with Nigella sativa seed extract (Thymoquinone) in experimentally induced Murine Lung Cancer Cell Line Model.". EKB Journal Management System, 6, 4, 2024, 566-587. doi: 10.21608/jmals.2024.410841
Zidane, A., Mahmoud, E., Tarek, M., Mokhamer, E. (2024). 'Molecular evaluation of the anticancer potential of 1,3,4-oxadiazole-2-thiones derivative and its synergetic action with Nigella sativa seed extract (Thymoquinone) in experimentally induced Murine Lung Cancer Cell Line Model.', EKB Journal Management System, 6(4), pp. 566-587. doi: 10.21608/jmals.2024.410841
Zidane, A., Mahmoud, E., Tarek, M., Mokhamer, E. Molecular evaluation of the anticancer potential of 1,3,4-oxadiazole-2-thiones derivative and its synergetic action with Nigella sativa seed extract (Thymoquinone) in experimentally induced Murine Lung Cancer Cell Line Model.. EKB Journal Management System, 2024; 6(4): 566-587. doi: 10.21608/jmals.2024.410841

Molecular evaluation of the anticancer potential of 1,3,4-oxadiazole-2-thiones derivative and its synergetic action with Nigella sativa seed extract (Thymoquinone) in experimentally induced Murine Lung Cancer Cell Line Model.

Journal of Medical and Life Science
Volume 6, Issue 4, December 2024, Pages 566-587    PDF (1.91 M)
Document Type: Original Article
DOI: 10.21608/jmals.2024.410841
Authors
Abdel Aziz Zidane1; Elsayed Abdel Rehem Mahmoud2; Mahmoud Tarek1; El-Hassan Mokhamer* 1
1Zoology Department, Faculty of Science, Damanhour University, Egypt
2Chemistry Department, Faculty of Science, Damanhour University, Egypt
Abstract
Lung cancer persistently poses as a primary factor in cancer-linked deaths globally, necessitating novel treatment strategies. This investigation appraises the anti-tumor potential of Thymoquinone (TQ) and 1,3,4-oxadiazole derivatives independently and jointly against lung malignancy. immunohistochemical (IHC) analysis exhibited meaningful alteration of Bcl-2, CD4, and CD8 manifestation, signifying heightened apoptosis and immune response. Molecular studies demonstrated the compounds' ability to adjust key genes involved in cancer development, specifically Caspase-1 and mTOR pathways. The combined therapy exhibited synergistic impacts, suggesting a promising approach for lung cancer management. These conclusions highlight the potential of TQ and 1,3,4-oxadiazole as effective therapeutic agents, warranting further clinical exploration and research.
Keywords
Lung cancer; Thymoquinone; 1; 3; 4 oxadiazole; Bcl2; CD4; CD8; mTOR; Caspase1
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