Postmortem Levels of Human Vitreous Humor Sodium, Potassium, Magnesium and Glucose in Different Causes of Death.
Hassan, A., Ghanem, A., Abo El-Atta, H., Hasan, A., Abd El Rahman, H. (2025). Postmortem Levels of Human Vitreous Humor Sodium, Potassium, Magnesium and Glucose in Different Causes of Death.. EKB Journal Management System, 33(2), 31-49. doi: 10.21608/mjfmct.2025.350072.1093
Amr Mohammed Hassan; Abdel Aziz Ghanem; Hend H.M Abo El-Atta; Ahmed S. Hasan; Heba Allah Abd El Rahman. "Postmortem Levels of Human Vitreous Humor Sodium, Potassium, Magnesium and Glucose in Different Causes of Death.". EKB Journal Management System, 33, 2, 2025, 31-49. doi: 10.21608/mjfmct.2025.350072.1093
Hassan, A., Ghanem, A., Abo El-Atta, H., Hasan, A., Abd El Rahman, H. (2025). 'Postmortem Levels of Human Vitreous Humor Sodium, Potassium, Magnesium and Glucose in Different Causes of Death.', EKB Journal Management System, 33(2), pp. 31-49. doi: 10.21608/mjfmct.2025.350072.1093
Hassan, A., Ghanem, A., Abo El-Atta, H., Hasan, A., Abd El Rahman, H. Postmortem Levels of Human Vitreous Humor Sodium, Potassium, Magnesium and Glucose in Different Causes of Death.. EKB Journal Management System, 2025; 33(2): 31-49. doi: 10.21608/mjfmct.2025.350072.1093

Postmortem Levels of Human Vitreous Humor Sodium, Potassium, Magnesium and Glucose in Different Causes of Death.

Mansoura Journal of Forensic Medicine and Clinical Toxicology
Volume 33, Issue 2, July 2025, Page 31-49  XML PDF (1.19 MB)
Document Type: Original Article
DOI: 10.21608/mjfmct.2025.350072.1093
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Authors
Amr Mohammed Hassan1; Abdel Aziz Ghanem1; Hend H.M Abo El-Attaorcid 2; Ahmed S. Hasan3; Heba Allah Abd El Rahman email orcid 1
1Forensic Medicine and Clinical Toxicology Department Faculty of Medicine, Mansoura University
2Forensic Medicine and Clinical Toxicology Department Faculty of Medicine, Mansoura University, Egypt
3Clinical Pathology Department, Faculty of Medicine Mansoura University
Abstract
Vitreous humor (VH) is a highly valuable sterile accessible sample in postmortem chemistry. Relatively few studies concerned the VH postmortem analysis in differentiating between causes of death. The current prospective cross-sectional study aimed at estimating VH postmortem levels of Sodium (Na), Potassium (K), Magnesium (Mg) and Glucose as differentiating variables between (traumatic, pathological and toxicological) causes of death. In the current work, VH samples were obtained from adult autopsied cases (n= 70) with postmortem interval less than 24 hours and after exclusion of ocular diseases or trauma. The traumatic group had significantly higher VH levels of (Na, K and Mg), in line with significantly lower VH glucose compared to Pathological group. The VH glucose levels were significantly higher in toxicological group compared to traumatic group. Toxicological group had significantly higher VH Na and VH Mg levels as well as significant lower VH glucose levels compared to pathological group. The VH glucose achieved the highest accuracy (84.6 %) in the receiver operating characteristic (ROC) curve analysis for differentiating between traumatic and pathological causes of deaths; followed by VHK, (82.6 %). Also, the VH glucose had the highest accuracy (76.2 %) in discriminating pathological from toxicological deaths followed by VH Na (70.8 %). Moreover, VH glucose achieved accuracy of (74.2 %) in differentiating between Traumatic and Toxicological deaths. To conclude, postmortem VH electrolytes and glucose levels showed variable patterns in different death causes. Hence, VH analysis could be used as adjuvant tool in suspecting cause of death; particularly the VH glucose level.
Keywords
Postmortem chemistry; Vitreous; Electrolytes; Glucose; ROC analysis
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