Correlation between Insulin Resistance and Thyroid Dysfunction
Ahmed, M., Elhadidy, K., Kamel, M., Mohamed, S., Hamed, A. (2025). Correlation between Insulin Resistance and Thyroid Dysfunction. EKB Journal Management System, 6(1), 203-216. doi: 10.21608/ejmr.2024.330025.1719
Mahmoud Hassan Ahmed; Khaled Elsayed Elhadidy; Mahmoud Farid Kamel; Sahar Mohamed Mostafa Mohamed; Ahmed Moheyeldien Hamed. "Correlation between Insulin Resistance and Thyroid Dysfunction". EKB Journal Management System, 6, 1, 2025, 203-216. doi: 10.21608/ejmr.2024.330025.1719
Ahmed, M., Elhadidy, K., Kamel, M., Mohamed, S., Hamed, A. (2025). 'Correlation between Insulin Resistance and Thyroid Dysfunction', EKB Journal Management System, 6(1), pp. 203-216. doi: 10.21608/ejmr.2024.330025.1719
Ahmed, M., Elhadidy, K., Kamel, M., Mohamed, S., Hamed, A. Correlation between Insulin Resistance and Thyroid Dysfunction. EKB Journal Management System, 2025; 6(1): 203-216. doi: 10.21608/ejmr.2024.330025.1719

Correlation between Insulin Resistance and Thyroid Dysfunction

Egyptian Journal of Medical Research
Volume 6, Issue 1, January 2025, Page 203-216  XML PDF (655.51 K)
Document Type: Original Article
DOI: 10.21608/ejmr.2024.330025.1719
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Authors
Mahmoud Hassan Ahmed1; Khaled Elsayed Elhadidy1; Mahmoud Farid Kamel1; Sahar Mohamed Mostafa Mohamed2; Ahmed Moheyeldien Hamed email 1
1Internal Medicine Department, Faculty of medicine, Beni-Suef University
2Medical biochemistry and molecular biology Department, Faculty of medicine, Beni-Suef University
Abstract
Background: Thyroid hormones T3 and T4 maintain a fine balance of glucose homeostasis by acting as insulin agonistic and antagonistic. Objective: In this study we aim to asses insulin resistance in patients who have thyroid disorders. Methods:  the current inquiry was a case-control study with 60 participants. The subjects were split into three equal groups: 20 individuals with a hypothyroidism, 20 individuals with hyperthyroidism and
20 euthyroid individuals. Gathering medical history and measure body mass index. In addition, check the thyroid gland locally. Testing for HOMA-IR, TSH, Free T3, and Free T4 .Results: There was a statistically significant moderate negative linear correlation between free T4 and HOMA-IR (r=-0.491, p=0.028) only in hypothyroid patients' group. There was a statistically significant moderate negative linear correlation between free T3 and HOMA-IR (r=-0.505, p<0.001) in all studied population, however this significant correlation lost in studying each group separately (p-values >0.05). There was a statistically significant moderate positive linear correlation between TSH and  HOMA-IR (r=0.644, p<0.001) in all studied population, however this significant correlation lost in studying each group separately (p-values >0.05). Conclusion: There is a significant association between thyroid dysfunction and HOMA-IR.
Keywords
Thyroid; Insulin Resistance; HOMA-IR
References
 

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