Study of Gut Klebseilla in Biliary Atresia | ||||
| The Medical Journal of Cairo University | ||||
| Volume 92, Issue 12, December 2024, Page 1067-1070 PDF (24.99 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/mjcu.2024.411333 | ||||
 View on SCiNiTO | ||||
| Author | ||||
| MOHAMMED A. EL-GUINDI, M.D.*; ALIF A. ALLAM, M.D.*; OLA A. FOUAD, M.D.*; SAMAH M. AWAD, M.D.** and MONA A. SEIF EL DEEN, M.Sc.*** | ||||
| The Department of Pediatric Hepatology, Gastroenterology, and Nutrition*, National Liver Institute, Menoufia University, Department of Medical Microbiology and Immunology**, National Liver Institute, Menoufia University and Pediatric Department, Damanhour Health Administration, Beheira Governorate***, Ministery of Health and Population | ||||
| Abstract | ||||
| Abstract Background: Biliary atresia (BA) is a neonatal cholestasis disease that is characterized by fibrosclerosing and inflammato-ry obliteration of the biliary tracts, which leads to progressive liver damage. It is the most common cause of cholestasis in the first 3 months of life presented by progressive conjugated jaundice, pale acholic stools and dark with later ones being, as-cites, portal hypertension and splenomegaly. The recommend-ed treatment is kasai portoenterostomy & liver transplantation. Characterization of gut klebsiella profile in infants with biliary atresia can provide valuable information and potential disease biomarkers. Aim of Study: Our study aims to characterize the gut Kleb-siellain infants with biliary atresia. Material and Methods: This study was a case control study that included 10 infants diagnosed as BA&10 age-matched healthy infants as a control group. Results: Increase level of Klebsiellain BA group more than control group. There was significant difference between BA group & control group (p-value >0.05). Conclusion: Increased level of gut Klebsiella is associated with the incidence of biliary atresia. | ||||
| Keywords | ||||
| Gut; Klebseilla; Biliary Atresia | ||||
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