Impact of Selenium nanoparticles on Biochemical parameters of Doxorubicin induced hepatotoxicity in Rat model
Albalawi, S., Awadalla, A., Hussein, A., Youssef, M. (2024). Impact of Selenium nanoparticles on Biochemical parameters of Doxorubicin induced hepatotoxicity in Rat model. EKB Journal Management System, 65(2), 1-8. doi: 10.21608/mjcc.2024.411466
Saad M. Albalawi; Amira Awadalla; Abdelaziz M. Hussein; Magdy M. Youssef. "Impact of Selenium nanoparticles on Biochemical parameters of Doxorubicin induced hepatotoxicity in Rat model". EKB Journal Management System, 65, 2, 2024, 1-8. doi: 10.21608/mjcc.2024.411466
Albalawi, S., Awadalla, A., Hussein, A., Youssef, M. (2024). 'Impact of Selenium nanoparticles on Biochemical parameters of Doxorubicin induced hepatotoxicity in Rat model', EKB Journal Management System, 65(2), pp. 1-8. doi: 10.21608/mjcc.2024.411466
Albalawi, S., Awadalla, A., Hussein, A., Youssef, M. Impact of Selenium nanoparticles on Biochemical parameters of Doxorubicin induced hepatotoxicity in Rat model. EKB Journal Management System, 2024; 65(2): 1-8. doi: 10.21608/mjcc.2024.411466

Impact of Selenium nanoparticles on Biochemical parameters of Doxorubicin induced hepatotoxicity in Rat model

Mansoura Journal of Chemistry
Volume 65, Issue 2, April 2024, Page 1-8  XML PDF (1.05 MB)
Document Type: Original Article
DOI: 10.21608/mjcc.2024.411466
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Authors
Saad M. Albalawi* 1; Amira Awadalla2; Abdelaziz M. Hussein3; Magdy M. Youssef4
1Biochemistry Division, Chemistry Department, Faculty of Science, Mansoura University
2Center of Excellence for Genome and Cancer Research, Urology and Nephrology Center
3Medical Physiology Department, Faculty of Medicine, Mansoura University, Mansoura
4Biochemistry Division, Chemistry Department, Faculty of Science, Mansoura University, Mansoura 35516, Egypt
Abstract
This study investigates the mitigative effects of Selenium (Se) against Doxorubicin (DOX)-induced hepatotoxicity, particularly focusing on gene expressions of BCL2 and BAX as markers of cellular survival and apoptosis. Chemotherapy, notably with DOX, while effective against various malignancies, poses risks of hepatotoxicity, characterized by hepatocyte necrosis and fibrosis. The study explores Se's role, a vital trace mineral integral to Selenium nanoparticles, in combating oxidative stress induced by DOX. Employing a controlled experimental design, gene expressions in four groups (Control, Se, DOX, and DOX + Se) were studied using quantitative real-time PCR. Results showed that Se supplementation alone had minimal impact on BCL2 and BAX expressions. However, DOX treatment significantly decreased BCL2 levels and increased BAX levels, underscoring its hepatotoxic potential. The combined DOX+Se treatment moderated these effects, partially restoring BCL2 levels and reducing BAX expression, suggesting Se's protective capability against DOX-induced gene expression dysregulation. These results highlight the potential of Se in ameliorating the adverse effects of DOX, providing insights into protective strategies against chemotherapy-induced hepatotoxicity.
Keywords
Doxorubicin; hepatotoxicity-selenium nanoparticles- BAX- BCL2
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