CONVENIENT SYNTHESIS OF SOME NEW THIAZOLIDIN-4-ONE, CHROMEN-2-IMINE AND PYRROL-2-ONE DERIVATIVES CONTAINING FURAN MOIETY | ||||
| Mansoura Journal of Chemistry | ||||
| Volume 65, Issue 2, April 2024, Page 46-50 PDF (1.09 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/mjcc.2024.411471 | ||||
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| Authors | ||||
| Tajdida- imhimmed Musbah* 1; Noha S. Mohammed1; Ahmed Mekabaty2 | ||||
| 1Chemistry Department, Faculty of Science, Mansoura University, El-Gomhoria Street, ET-35516 Mansoura, Egypt. | ||||
| 2Chemistry Department, Faculty of Science, Mansoura University | ||||
| Abstract | ||||
| The attending work used Gewald's approach to produce ethyl 2-amino-4,5-diphenylfuran-3-carboxylate (2) by condensing benzoin (1) with ethyl cyanoacetate while stirring in dimethylformamide containing a catalytic amount of diethylamine. Through its interactions with practical chemical reagents, this 2-aminofuran derivative worked as a crucial synthon for the synthesis of novel thiazolidin-4-one, chromen-2-imine, and pyrrol-2-one derivatives. It was also addressed how the novel furan derivatives were achieved mechanistically | ||||
| Keywords | ||||
| Furan; thiazolidinone; chromene; pyrrolone; Gewald’s methodology | ||||
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